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Home » ... » - Faculty » Faculty Pages » Fabry, Zsuzsanna |
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Fabry, Zsuzsanna
Zsuzsanna Fabry
Professor
Research Area: Immunopathology, Neuroimmunology, Multiple Sclerosis
Home Dept: Department of Pathology and Laboratory Medicine
Affiliated Depts: Molecular and Environmental Toxicology
Address
6130 Medical Sciences Center
1300 University Avenue
Madison, WI 53706
Phone - 608/265-8716
Email
Research
The influx of T lymphocytes into the CNS is an important part of the immunopathology of various autoimmune and infectious diseases in the brain,such as Multiple Sclerosis (MS). My laboratory is using animal models to study this process. One of our goals is to interfere with autoimmune TH1-type T cells in the CNS by inhibiting their traffic across the blood-brain barrier or influencing their cytokine production. We also propose that activation of protective TH2-type immunity during the course of MS can lead to a remission phase in the disease.
A second focus of my laboratory is post-traumatic tissue regeneration in the brain. Tissue injury could happen as a result of autoimmune process or direct physical damage. Currently, we are characterizing new methods, involving the immune system, to accelerate tissue repair in the CNS.
Our ultimate goal is to design new treatments for Th1-type autoimmune diseases, such as MS.
Publications- Zozulya AL, Reinke E, Baiu DC, Karman J, Sandor M, Fabry Z. Dendritic Cell Transmigration through Brain Microvessel Endothelium Is Regulated by MIP-1aChemokine and Matrix Metalloproteinases.
J Immunol. 2007 Jan 1;178(1):520-9. - Karman J, Chu HH, Co DO, Seroogy CM, Sandor M, Fabry Z. Dendritic cells amplify T cell-mediated immune responses in the central nervous system. J Immunol. 2006 Dec 1;177(11):7750-60.
- Reinke EK, Johnson MJ, Ling C, Karman J, Lee J, Weinstock JV, Sandor M, Fabry Z. Substance P receptor mediated maintenance of chronic inflammation in EAE. J Neuroimmunol. 2006 Nov;180(1-2):117-25. Epub 2006 Aug 30.
- Ling C, Sandor M, Suresh M, Fabry Z. Traumatic injury and the presence of antigen differentially contribute to T-cell recruitment in the CNS. J Neurosci. 2006 Jan 18;26(3):731-41.
- Reinke E, Fabry Z. Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides. Immunol Lett. 2006 Apr 15;104(1-2):102-9. Epub 2005 Dec 5. Review.
- Baiu DC, Barger B, Sandor M, Fabry Z, Hart MN. Autoantibodies to vascular smooth muscle are pathogenic for vasculitis. Am J Pathol. 2005 Jun;166(6):1851-60.
Check PubMed for other publications by Zsuzsanna Fabry
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