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Drinkwater, Norman R.
 Norman R. Drinkwater, PhD
Professor
Research Area: Genetics of Environmental Carcinogenesis and Mutagenesis. Molecular mechanisms of carcinogenesis and mutagenesis. Genetic susceptibility to carcinogenesis
Home Dept: Department of Oncology, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
McArdle Lab for Cancer Research
815A McArdle
1400 University Avenue
Madison, WI 53706
Phone - 608/262-7992 - Email
Research
Genetic factors can play an important role in determining an individual’s risk for developing cancer. We are studying inbred strains of mice that are highly sensitive to tumor induction in specific tissues as a model for understanding the mechanism of action of cancer susceptibility genes. In many cases, these genes also play an important role in regulating the proliferation or differentiation of normal cells. We are currently attempting to determine the molecular identities of several cancer susceptibility genes using a “reverse genetic” approach, based on first mapping the genes and then using this positional information as starting points for molecular cloning. In a research endeavor highly related to the interests of the National Toxicology Program (NTP), the Drinkwater lab is mapping genes that contribute to the differential susceptibilities of the C57 and C3H strains to hepatocarcinogenesis induced by environmental chemicals. The f1 of these strains is now the standard in toxicological testing.
Publications- Thomae TL, Stevens EA, Liss AL, Drinkwater NR, Bradfield CA. The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin is modified by a locus on mouse chromosome 3. Mol Pharmacol. 2006 69(3):770-5.
- Drew JC, Kastenmeier AS, Drinkwater NR. Ancestral bias in the Hras1 gene and distal Chromosome 7 among inbred mice. Mamm Genome. 2007 Sep 29; [Epub ahead of print]
- Chiaverotti, T.A., and Drinkwater, N.R. 2003. C57BR/cdJ Hepatocarcinogen Susceptibility Genes Act Cell-Autonomously in C57BR/cdJ C57BL/6J Chimeras. Cancer Res., 63:4914-491.
- Bugni, J.M., and Drinkwater, N.R. 2003. Representational Difference Analysis of Gene Expression. In: W.S. El-Deiry (Ed.), Methods in Molecular Biology, Vol. 222: Tumor Suppressor Genes: Pathways and Isolation Strategies, Chap. 24, pp. 385-397. Totowa, NJ: Humana Press Inc.
- Yao, G., Craven, M., Drinkwater, N., and Bradfield, C.A. 2004. Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor. PLOS Biol., 2:355-367.
- Kelley, M.R., Tompkinson, A.E., Williams, K.J., Drinkwater, N.R., and Fung, V.A. 2004. Frontiers of Mutagenesis and DNA Repair: a Workshop. Cancer Res., 64:3357-3360.
- Bilger, A., Bennett, L.M., Carabeo, R.A., Chiaverotti, T.A., Dvorak, C., Liss, K.M., Schadewald, S.A., Pitot, H.C., and Drinkwater, N.R. 2004. A Potent Modifier of Liver Cancer Risk on Distal Mouse Chromosome 1: Linkage Analysis and Characterization of Congenic Lines. Genetics, 167:859-866.
Check PubMed for other publications by Norman R. Drinkwater
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