 |
 |
 |
 |
 |
Home » ... » - Faculty » Faculty Pages » Gould, Michael N. |
 |
 |
|
 |
|
 |
 |
|
|
|
Gould, Michael N.
 Michael N. Gould
Professor
Research Area: Molecular Biology of Breast Cancer. Identification of genes that prevent breast cancer. Signaling pathway differences between H-Ras and K-Ras oncogenes and role in organ-specific carcinogenesis. Molecular basis of selective cell death and proliferation inhibition through study of effects of monoterpene drugs and other potential chemoprotective agents. Breast cancer risk assessment by surrogate biomarkers.
Home Dept: School of Medicine
Affiliated Depts: Molecular and Environmental Toxicology
Address
McArdle Lab for Cancer Research
Room 506
1400 University Avenue
Madison, WI 53706
608/263-6026 - Email
Patents
1997-Assay for carcinoma proliferative status by measuring NGAL expression level
1997- Identification of differentially expressed genes
1993-Method for producing a recombinant mammal in vivo
Research
Our laboratory studies the developmental etiology of chemically induced breast cancer. The laboratory studies the role of oncogenes in this process and is identifying novel suppressor genes that prevent carcinogenesis. Several genes have been identified, and further research is underway to provide a better understanding of the role of modifier genes in breast cancer risk. We now have demonstrated that rats are most susceptible to N-nitroso-N-methylurea (NMU) prior to puberty, suggesting that the immature breast is most susceptible to toxicant exposure that will ultimately cause breast cancer. We also are characterizing the mechanisms through which limonene and related terpenes suppress mammary carcinogenesis. Our three major projects are:
Breast cancer genetics: Initially, using animal models we are specifically looking for genes that prevent breast cancer. Once identified, these genes will provide a better understanding of the role of modifier genes in breast cancer risk and also provide anticancer drug development targets.
Oncogenes, Ras signaling: We are approaching two questions in the area of carcinogenesis -- How do H-Ras and K-Ras differ in their signaling pathways? Which of these pathwyas lead to organ specific carcinogenesis?
Breast cancer chemoprevention and therapy: Our laboratory is developing a novel class of anticancer drugs, the monoterpenes. They selectively induce apoptosis and inhibit proliferation in cancer cells. We are seeking the molecular basis of this important selectivity by investigating, the effects of these drugs on cell cycle associated protein and signaling pathways associated with cytostasis and apoptosis. Additionally, we are performing studies with other potential chemopreventive agents, as well as identifying surrogate biomarkers for breast cancer risk.
Publications- Samuelson DJ et.al. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci U S A. 2007104(15):6299-304.
- Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, Dove WF. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A. 2007104(10):4036-41.
- Rose-Hellekant TA, Schroeder MD, Brockman JL, Zhdankin O, Bolstad R, Chen KS, Gould MN, Schuler LA, Sandgren EP. Estrogen receptor-positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss. Oncogene. 2007 26(36):5238-46.
- Cotroneo MS, Haag JD, Zan Y, Lopez CC, Thuwajit P, Petukhova GV, Camerini-Otero RD, Gendron-Fitzpatrick A, Griep AE, Murphy CJ, Dubielzig RR, Gould MN. Characterizing a rat Brca2 knockout model. Oncogene. 2007 26(11):1626-35.
- Woditschka S, Haag JD, Waller JL, Monson DM, Hitt AA, Brose HL, Hu R, Zheng Y, Watson PA, Kim K, Lindstrom MJ, Mau B, Steele VE, Lubet RA, Gould MN. Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. Cancer Res. 2006 66(13):6884-91.
- Cotroneo MS, Merry GM, Haag JD, Lan H, Shepel LA, Gould MN. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Oncogene. 2006 25(36):5011-7.
- Ariazi JL, Haag JD, Gould MN. Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility. Mol Carcinog. 2005 44(3):193-201.
- Samuelson DJ, Aperavich BA, Haag JD, Gould MN. Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5. Cancer Res. 2005 65(21):9637-42.
- Berchtold CM, Chen KS, Miyamoto S, Gould MN. Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. Cancer Res. 2005 65(18):8558-66.
- Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Zan Y, Haag, JD, Chen KS, Shepel LA, Wigington D, Wang YR, Hu R, Lopez-Guajardo CC, Brose HL, Porter KI, Leonard RA, Hitt AA, Schommer SL, Elegbede AF, Gould MN. Nature Biotechnology 2003 June:21(6):645-651 (Epub 2003 May 18. Comment in: Nat Biotechnol. 2003 June;21(6):625-7.)
Check PubMed for other publications by Michael Gould
|
|
