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Jefcoate, Colin R.
 Colin R. Jefcoate, PhD
Professor
Research Area: Roles of cytochrome P4501B1 and Ah Receptor in fat pad development, bone marrow toxicity and carcinogenesis in susceptible mouse strains (intestines, prostate, and mammary gland). Effects of polycyclic aromatic hydrocarbons and PCBs in these processes Molecular mechanism of cholesterol conversion to steroid hormones. Effects of obesity and steroid synthesis and carcinogenesis.
Home Dept: Molecular and Cellular Pharmacology, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
Medical Sciences Center
1300 University Avenue
Madison, WI 53706
Phone: 608/263-3975 - Email
Research
Our research addresses signaling mechanisms involving P450 cytochromes. These regulate activity at nuclear receptors regulated by three types of activator.
cholesterol/steroid hormonesfatty acids and metabolitesAh receptor/PCB's and polycyclic aromatic hydrocarbons
Publications- Duan H, Jefcoate CR. The predominant cAMP-stimulated 3 x 5 kb StAR mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability. J Mol Endocrinol. 2007 Feb;38(1-2):159-79.
- Yamazaki T, Matsuoka C, Gendou M, Izumi S, Zhao D, Artemenko I, Jefcoate CR, Kominami S. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein. Biochim Biophys Acta. 2006 Oct;1764(10):1561-7.
- Jefcoate CR. Liver X receptor opens a new gateway to StAR and to steroid hormones. J Clin Invest. 2006 Jul;116(7):1832-5.
- Tsuchiya Y, Nakajima M, Takagi S, Katoh M, Zheng W, Jefcoate CR, Yokoi T. Binding of steroidogenic factor-1 to the regulatory region might not be critical for transcriptional regulation of the human CYP1B1 gene. J Biochem (Tokyo). 2006 Mar;139(3):527-34.
- Galvan N, Page TJ, Czuprynski CJ, Jefcoate CR. Benzo(a)pyrene and 7,12-dimethylbenz(a)anthrecene differentially affect bone marrow cells of the lymphoid and myeloid lineages. Toxicol Appl Pharmacol. 2006 Jun 1;213(2):105-16.
- Hanlon PR, Cimafranca MA, Liu X, Cho YC, Jefcoate CR. Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 2005 Aug 22;207(1):39-58.
- Galvan N, Teske DE, Zhou G, Moorthy B, MacWilliams PS, Czuprynski CJ, Jefcoate CR. Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. Toxicol Appl Pharmacol. 2005 Feb 1;202(3):244-57.
Check PubMed for other publications by Colin R. Jefcoate ul>
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