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Home » ... » - Faculty » Faculty Pages » Jeffries, Thomas W. |
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Jeffries, Thomas W.
Thomas W. Jeffries, PhD
Professor
Research Area: Xylose. Yeasts. Metabolic Engineering. Alternative and Renewable Fuels. Microbial physiology and metabolic regulation as they apply to the use of lignocellulosic materials. Interdisciplinary research involving screening, scale-up, microbial biochemistry, and molecular genetics. Fermentation of xylose by yeasts. Use of xylanases, cellulases and ligninases in pulp and paper processing.
Home Dept: Bacteriology, College of Agricultural and Life Sciences
Affiliated Depts: Molecular and Environmental Toxicology
Address
14 Forest Products Lab
One Gifford Pinchot Dr
Madison, WI 53705
608/231-9453 - Email
Patents
2000-Disruption of the cytochrome C gene in xylose-fermenting yeast
1998-Method of removing color from kraft wood pulps
1996-Method of removing color from wood pulp using xylanase from streptomyces roseiscleroticus NRRL
1994- Xylanase from streptomyces roseiscleroticus NRRL-11019 for removing color from kraft wood pulps 1992-Xylose-fermenting yeast mutants
1987-Process for enhanced fermentation of xylose to ethanol
Research
Dr. Jeffries' research interests are in the areas of microbial physiology, metabolic regulation and metabolic engineering as they apply to the utilization of lignocellulosic materials. Research is interdisciplinary and involves genetic engineering of novel yeasts, strain screening, scale-up, microbial biochemistry, and molecular genetics. Particular areas of emphasis are the fermentation of xylose by yeasts and metabolic pathway engineering. Research activities include metabolic engineering in the xylose-fermenting yeast, Pichia stipitis; optimization of metabolic pathways in Saccharomyces cerevisiae; determination of rate-limiting steps in yeast fermentation and growth; alteration of intermediary metabolism to regulate energetics.
Publications- Jeffries TW. Engineering yeasts for xylose metabolism. Curr Opin Biotechnol. 2006 Jun;17(3):320-6. Epub 2006 May 18.
- Jeffries TW. Ethanol fermentation on the move. Nat Biotechnol. 2005 Jan;23(1):40-1.
- Jin YS, Cruz J, Jeffries TW. Xylitol production by a Pichia stipitis D-xylulokinase mutant. Appl Microbiol Biotechnol. 2005 Jul;68(1):42-5. Epub 2005 Jan 6.
- Jin YS, Laplaza JM, Jeffries TW. Saccharomyces cerevisiae engineered for xylose metabolism exhibits a respiratory response. Appl Environ Microbiol. 2004 Nov;70(11):6816-25.
- Jin YS, Jeffries TW. Stoichiometric network constraints on xylose metabolism by recombinant Saccharomyces cerevisiae. Metab Eng. 2004 Jul;6(3):229-38.
- Jeffries TW, Lynd LR. Introduction to microbial catalysis and engineering. Appl Biochem Biotechnol. 2004 Spring;113-116:323-4.
- Jeffries TW, Jin YS. Metabolic engineering for improved fermentation of pentoses by yeasts. Appl Microbiol Biotechnol. 2004 Feb;63(5):495-509. Epub 2003 Nov 1.
Check PubMed for other publications by Thomas W. Jeffries
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