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Home » ... » - Faculty » Faculty Pages » Mukthar, Hasan |
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Mukthar, Hasan
 Hasan Mukhtar, PhD
Professor
Research Area: Apoptosis, Chemical Carcinogenesis, Chemoprevention, Cytochrome P450, Metabolic Basis of Toxicity, Photocarcinogenesis, Tumor Promotion/Prevention.
Home Dept: Dermatology, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
Room 287 (Old Biochemistry Bldg)
420 Henry Mall
Madison, WI 53706
Phone: 608/263-3927
Email
Research
There are two major areas of investigation in our laboratory. The first area of research is related to defining the role of toxicants on cutaneous cytochome P450 and other enzymatic pathways in biotransformation of endogenous and exogenous chemicals to which skin comes in contact. We study the effect of environmental pollutants, carcinogens, ultraviolet radiation and ozone. Within this broad context, the role of cell cycle regulatory pathways in chemical and photocarcinogenesis and UV responses is studied. We have been at the forefront to examine the role of botanical antioxidants as photochemopreventive agents. Our laboratory was the first to document the role of polyphenols from green tea and pomegranate on environmental effects in the skin. These studies use a combination of human and murine approaches with classical cellular, biochemical, and molecular techniques. Our second area of research is on skin and prostate cancer prevention. We have shown that the polyphenolic fraction isolated from green tea and many other botanicals act as anti-inflammatory and anticarcinogenic agents and provide protection against all stages of multistage cutaneous carcinogenesis processes known as tumor initiation, tumor promotion, and tumor progression. We also examine the effects of botanical antioxidants for prevention and treatment of prostate cancer. These findings have received considerable national and international attention. Our recent studies demonstrating that topical application of green tea polyphenol and antioxidants from pomegranate to human skin results in protection against solar erythema and the associated cellular and molecular effects raises the possibility that botanical antioxidants may prove useful against the adverse effect of UV in the human population.
Publications- Adhami VM, Mukhtar H. Anti-oxidants from green tea and pomegranate for chemoprevention of prostate cancer. Mol Biotechnol. 2007 37(1):52-7.
- Siddiqui IA, Saleem M, Adhami VM, Asim M, Mukhtar H. Tea beverage in chemoprevention and chemotherapy of prostate cancer. Acta Pharmacol Sin. 2007 28(9):1392-408.
- Khan N, Mukhtar H. Tea polyphenols for health promotion. Life Sci. 2007 81(7):519-33. Review.
- Ahsan H, Reagan-Shaw S, Eggert DM, Tan TC, Afaq F, Mukhtar H, Ahmad N.
Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: implications for prevention of skin cancer. Photochem Photobiol. 2007 83(4):986-93. - Zaid MA, Afaq F, Syed DN, Dreher M, Mukhtar H. Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx. Photochem Photobiol. 2007 83(4):882-8.
- Syed DN, Afaq F, Mukhtar H. Pomegranate derived products for cancer chemoprevention. Semin Cancer Biol. 200717(5):377-85.
- Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007 255(2):170-81.
- Siddiqui IA, Afaq F, Adhami VM, Mukhtar H. Prevention of prostate cancer through custom tailoring of chemopreventive regimen. Chem Biol Interact. 2007 Mar 12; [Epub ahead of print].
- Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H. Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res. 2007 67(7):3475-82.
- Amin AR, Thakur VS, Paul RK, Feng GS, Qu CK, Mukhtar H, Agarwal ML. - SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proc Natl Acad Sci U S A. 2007 104(13):5419-24.
- Adhami VM, Malik A, Zaman N, Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Pasha FS, Saleem M, Mukhtar H. Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res. 2007 13(5):1611-9.
- Mukhtar H, Afaq F, Matsui MS. Fishing for allergens hiding as prohaptens. J Invest Dermatol. 2007 127(5):992-3.
- Khan N, Afaq F, Mukhtar H. Apoptosis by dietary factors: the suicide solution for delaying cancer growth. Carcinogenesis. 2007 28(2):233-9. Review.
- Kweon MH, Afaq F, Bhat KM, Setaluri V, Mukhtar H. A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21(WAF1/Cip1). Oncogene. 2007 26(24):3559-71.
Check PubMed for other publications by Hasan Mukhtar
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