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Home » ... » - Faculty » Faculty Pages » Prolla, Tomas |
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Prolla, Tomas
Tomas A. Prolla
Associate Professor
Research Area: DNA Repair. Cancer. Aging. Generation of animal models of human cancer syndromes using gene targeting in the mouse. Role of DNA repair in spontaneous and induced mutagenesis. Signal transduction pathways involved in DNA repair.
Home Dept: Genetics, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
5302A Genetics/Biotech
425 Henry Mall
Madison, WI 53706
608/265-5204 - Email
Patents
2006-Methods of screening for compounds that inhibit expression of biomarker sequences differentially
2003- Identification of gene expression alterations underlying the aging process in mammals
2003-Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
2003-Identification of genetic markers of biological age and metabolism
Research
My laboratory is currently focused on understanding the molecular basis of the aging process and common age-related human diseases through the use of large-scale gene expression analysis. We have recently characterized the gene expression profile of thousands of genes during the aging process of skeletal muscle and brain using “DNA-chips.” We are currently extending these studies to multiple tissues of mice, humans and rhesus monkeys. We complement these studies with the generation of transgenic and “knock-out” mice that overexpress or are deficient in specific genes, and analyze the influence of these interventions on the aging process. Other studies include the effects of DNA repair pathways in cancer, and the role of micronutrients in cancer prevention.
Publications- Sanz A, Hiona A, Kujoth GC, Seo AY, Hofer T, Kouwenhoven E, Kalani R, Prolla TA, Barja G, Leeuwenburgh C. Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice. Exp Gerontol. 2006 Nov 20;
- Megid WA, Ensenberger MG, Halberg RB, Stanhope SA, Kent-First MG, Prolla TA, Bacher JW. A novel method for biodosimetry. Radiat Environ Biophys. 2006 Oct 27
- Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Age and vitamin E-induced changes in gene expression profiles of T cells. J Immunol. 2006 Nov 1;177(9):6052-61.
- Weindruch R, Kayo T, Lee CK, Prolla TA. Effects of caloric restriction on gene expression. Nestle Nutr Workshop Ser Clin Perform Programme. 2002;6:17-28; discussion 28-32. Review. No abstract available.
- Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 8;126(5):941-54.
- Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis.Neurobiol Aging. 2006 Aug 3
- Kujoth GC, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations and apoptosis in mammalian aging. Cancer Res. 2006 Aug 1;66(15):7386-9.
- Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res. 2006 Jul 24;
- Leeuwenburgh C, Prolla TA. Genetics, redox signaling, oxidative stress, and apoptosis in mammalian aging. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):503-5.
- Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr. 2006 Feb;136(2):343-52.
- Hansen AB, Griner NB, Anderson JP, Kujoth GC, Prolla TA, Loeb LA, Glick E. Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst). 2006 Jan 5;5(1):71-9. pub 2005 Sep 13. PMID: 16165404 [PubMed - indexed for MEDLINE]
Check PubMed for other publications by Tomas A. Prolla
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