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Home » ... » - Faculty » Faculty Pages » Schuler, Linda |
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Schuler, Linda
 Linda A. Schuler, VMD, PhD
Professor
Research Area: Hormonal Effects in Breast Cancer and Human Development. Prolactin and related hormones' receptors, signaling and processing; cell specific actions on maternal and fetal tissues, and role in mammary cancer.
Home Dept: Comparative Bioscience, School of Veterinary Medicine
Affiliated Depts: Molecular and Environmental Toxicology
Address
4354B Veterinary Medicine Bldg
2015 Linden Drive
Madison, WI 53706
Phone: 608/263-9825 - Email
Research
The Schuler laboratory is interested in the interactions of prolactin and related hormones with other growth factors and hormones at fetal and maternal targets during pregnancy. They have extended studies on the actions of prolactin in mammary alveolar development during pregnancy to its role in the development and progression of mammary cancer. Using a variety of in vitro models, they examine control of receptor expression including receptor internalization and linkage to signal transduction, cell specific target genes, and signaling pathways employed. They have developed transgenic mouse models using a non-hormonally responsive, mammary specific promoter in order to examine interactions on preneoplastic processes in vivo.
Publications- Arendt LM, Rose-Hellekant TA, Sandgren EP, Schuler LA. Prolactin potentiates transforming growth factor alpha induction of mammary neoplasia in transgenic mice. Am J Pathol. 2006 Apr;168(4):1365-74.
- Lu JC, Piazza TM, Schuler LA. Proteasomes mediate prolactin-induced receptor down-regulation and fragment generation in breast cancer cells. J Biol Chem. 2005 Oct 7;280(40):33909-16. Epub 2005 Aug 15.
- Brockman JL, Schuler LA. Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):45-53.
- Gutzman JH, Nikolai SE, Rugowski DE, Watters JJ, Schuler LA. Prolactin and estrogen enhance the activity of activating protein 1 in breast cancer cells: role of extracellularly regulated kinase 1/2-mediated signals to c-fos. Mol Endocrinol. 2005 Jul;19(7):1765-78. Epub 2005 Mar 3.
Check PubMed for other publications by Linda A. Schuler
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