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Speigelman, Vladimir S.
 Vladimir S. Spiegelman, MD, PhD
Assistant Professor
Research Area: Cancer. Ubiquitin Ligases. Signal Transduction. Regulation of expression and function of beta-TrCP ubiquitin ligases, their role in signal transduction, embryogenesis, and in tumor development, with major emphasis on skin, breast, and prostate carcinogenesis.
Home Dept: Dermatology, School of Medicine and Public Health
Affiliated Depts: Molecular and Environmental Toxicology
Address
445 Henry Mall
Room 301
Madison, WI 53706
Phone: 608/265-8197 - Email
Research
Molecular Mechanisms of Cancer Development and Progression
Publications- Spiegelman V.S.,. Slaga T.J., Pagano M., Minamoto T., Ronai Z., Fuchs S.Y. Wnt/b-catenin signaling induces the expression and activity of bTrCP ubiquitin ligase receptor. 2000, Molecular Cell, 5, 877-882.
- Spiegelman V.S., Stavropoulos P., Latres E., Pagano M., Ronai Z., Slaga T.J, Fuchs S.Y. Induction of b-TrCP by JNK signaling and its role in the activation of NF-kB. 2001, JBC, 276: 29, 27152-27158
- Spiegelman V.S., Tang W., Chan A. M., Igarashi M., Aaronson S. A., Sassoon D. A., Katoh M., Slaga T. J. and Fuchs S. Y. Induction of Homologue of Slimb Ubiquitin Ligase Receptor by Mitogen Signaling. 2002, JBC, 277: 39, 36624-36630
- Bhatia N., Herter J. R., Slaga T. J., Fuchs S. Y., and Spiegelman V. S.* Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kB, Oncogene, 2002, 21, 1501-1509
- Bhatia N., and Spiegelman V. S. Activation of Wnt/b-catenin/Tcf signaling in mouse skin carcinogenesis. 2005, Molecular Carcinogenesis, 42, 213-221.
- Noubissi F., Elcheva I., Bhatia N., Shakoori A., Ougolkov A., Liu J., Minamoto T., Ross J., Fuchs S.Y., and Spiegelman V.S. CRD-BP mediates stabilization of bTrCP1 and c-myc mRNA in response to b-catenin signaling. 2006, Nature, 441, 898-901.
- Bhatia N., Elcheva I., Saleem M., Dlugosz A., Mukhtar H., and Spiegelman V. S. Gli2 is targeted for ubiquitination and degradation by b-TrCP ubiquitin ligase receptor. 2006, JBC, 281: 28, 19320-19326
Check PubMed for other publications by Vladimir S. Spiegelman
Vladimir Speigelman (left)
Rohinton Tarapore (right)
Photo Credit: Chris Frazee, Media Solutions (bottom photo only)
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