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Home » ... » - Faculty » Faculty Pages » Watters, Jyoti |
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Watters, Jyoti
 Jyoti Watters, PhD
Assistant Professor
Research Area: Understanding the molecular signal transduction pathways in microglia in response to estrogens and extracellular adenine nucleotides that modulate their production of neurotoxic inflammatory mediators.
Home Dept: School of Veterinary Medicine
Affiliated Depts: Molecular and Environmental Toxicology; Endocrine-Reproductive Physiology; Neuroscience; Comparative Biomedical Sciences; Respiratory Neurobiology; Cell & Molecular Biology
Address
4470 Veterinary Medicine Building
2015 Linden Drive
Madison, WI 53706
Phone: 608/262-1016 - Email
Research
Our research interests are in the signal transduction mechanisms governing microglial cell responses to extracellular adenine nucleotides and estrogens, agents that our data suggest may exert neuroprotective effects in the brain following several types of neurotoxic injuries. The role of the MAP kinase pathways in controlling microglial cell production of inflammatory mediators and how hypoxia and/or reoxygenation injury alters their signaling responses to purinergic receptor activation are of primary interest.
Publications- Potucek YD, Crain JM, Watters JJ. Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression. Neurochem Int. 2006 Jul;49(2):204-14. Epub 2006 Jun 2. Review. PMID: 16735081 [PubMed - indexed for MEDLINE]
- Nikodemova M, Duncan ID, Watters JJ. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia. J Neurochem. 2006 Jan;96(2):314-23. Epub 2005 Dec 8. PMID: 16336636 [PubMed - indexed for MEDLINE]
- Brautigam VM, Frasier C, Nikodemova M, Watters JJ. Purinergic receptor modulation of BV-2 microglial cell activity: potential involvement of p38 MAP kinase and CREB. J Neuroimmunol. 2005 Sep;166(1-2):113-25. PMID: 15979729 [PubMed - indexed for MEDLINE]
- Watters JJ, Schartner JM, Badie B. Microglia function in brain tumors. J Neurosci Res. 2005 Aug 1;81(3):447-55. Review. PMID: 15959903 [PubMed - indexed for MEDLINE]
Check PubMed for other publications by Joyti Watters
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