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Home » ... » - Faculty » Faculty Pages » Bjorling, Dale |
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Bjorling, Dale
Dale Bjorling, DVM
Professor
Research Area: Environmental estrogen and bladder inflammation and carcinogenesis; veterinary surgery
Home Dept: School of Veterinary Medicine
Affiliated Depts: Molecular and Environmental Toxicology
Address
2023 Veterinary Medicine Bldg
2015 Linden Drive
Madison, WI 53706
Phone - 608/263-4808 - Email
Research
Research in the Bjorling laboratory indicates that proliferation of epithelial cells lining the bladder is increased by exposure to estrogen. Dr. Bjorling’s laboratory has also found that estrogen may mediate the response of animals to noxious somatic stimuli (mechanical and thermal), particularly in the presence of visceral inflammation. These findings are of particular relevance to the potential effects of environmental contaminants on human health for the following reasons:
1. Estrogenic compounds in food and the environment may be present in sufficient quantities to affect pain responses;
2. It has been demonstrated that a primary factor in initiating of cancer of the bladder is exposure of the epithelium of the bladder to toxicants excreted in the urine. Dr. Bjorling’s observation that estrogen affects proliferation of bladder epithelial cells suggests that estrogenic compounds may contribute to malignant transformation of bladder cells; and
3. They have demonstrated that the balance between the primary estrogen receptors (ER) shifts from predominantly ERb in normal cells to equivalent amounts of ERa and ERb in bladder cancer cell lines as well as samples of transitional cell carcinoma in the bladders of humans, providing further evidence of a potential role for estrogenic compounds in initiation of bladder cancer.
Publications- Schmiedt CW, Bjorling DE. Accidental prehension and suspected transmucosal or oral absorption of fentanyl from a transdermal patch in a dog. Vet Anaesth Analg. 2007 Jan;34(1):70-3.
- Danova NA, Robles-Emanuelli JC, Bjorling DE. Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs. Vet Surg. 2006 Jun;35(4):337-40.
- Jerde TJ, Mellon WS, Bjorling DE, Nakada SY. Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in novel human cell culture and porcine in vivo ureteral obstruction models.
J Pharmacol Exp Ther. 2006 Jun;317(3):965-72. - Guerios SD, Wang ZY, Bjorling DE. Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice. Neurosci Lett. 2006 Jan 16;392(3):193-7. Epub 2005 Oct 3.
- Guerios SD, Wang ZY, Bjorling DE. Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice. Neurosci Lett. 2006 Jan 16;392(3):193-7.
- Adams WM, Bjorling DE, McAnulty JE, Green EM, Forrest LJ, Vail DM. Outcome of accelerated radiotherapy alone or accelerated radiotherapy followed by exenteration of the nasal cavity in dogs with intranasal neoplasia: 53 cases (1990-2002). J Am Vet Med Assoc. 2005 Sep 15;227(6):936-41
- Li G, Barnes D, Butz D, Bjorling D, Cook ME. 10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo. J Lipid Res. 2005 Oct;46(10):2134-42. Epub 2005 Aug 1. PMID: 16061956
Check PubMed for other publications by Dale Bjorling
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