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Home » ... » - Faculty » Faculty Pages » Tibbetts, Randal S. |
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Tibbetts, Randal S.
Randal Tibbetts, PhD
Associate Professor
Research Area- Ataxia-telangiectasia (A-T) and breast cancer. Impact of environmental DNA-damaging insults on cellular physiology
Home Dept - Pharmacology
Affiliated Depts - Molecular and Environmental Toxicology; Cellular and Molecular Biology
Address
School of Medicine and Public Health
3675 Medical Sciences Center
1215 Linden Dr.
Madison, WI 53706
Phone: 608/ 262-0027 - Email
Research: Work in the Tibbetts laboratory is aimed at understanding key signal transduction pathways that control cellular responses to DNA damage induced by environmental insults such as UV light and gamma-radiation. The bulk of this work is directed toward the related DNA damage-response kinases ATM (ataxia-telangiectasia) and ATR (ATM-Rad3-related). ATM and ATR, and their orthologs in lower eukaryotes, function as apical DNA damage-signaling kinases that regulate diverse cellular processes including cell cycle checkpoint activation, DNA repair, gene transcription, and apoptosis. ATM and ATR have both been implicated as tumor suppressor genes that are mutated in human cancer. In addition, mutations in ATM are causally associated with ataxia-telangiectasia (A-T), a syndrome of cancer, neurodegeneration and premature aging that affects approximately 1 in 40,000 births. ATM is a well established tumor suppressor gene and its mutation has been strongly linked to sporadic and familial cases of breast cancer. ATM research is highly relevant for understanding the impact of environmental DNA-damaging insults on cellular physiology.
Publications:- Shanware NP, Trinh AT, Williams LM, and Tibbetts RS. (2007). Coregulated ATM and casein kinase sites modulate CREB-coactivator interactions in response to DNA damage. J Biol Chem. 282:6283-6291.
- Shi Y, Dodson GE, Mukhopadhyay P, Shanware NP, Trinh AT, and Tibbetts RS. (2007). Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phospho-specific antibodies. J Biol Chem. 282:9236-9243.
- Wu ZH, Shi Y, Tibbetts RS, Miyamoto S. (2006). Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science. 311:1141-6.
- Dodson GE and Tibbetts RS. (2006). DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem. 281:1692-7.
- Shi Y, Dodson GE, Shaikh S, Rundell K, and Tibbetts RS. (2005). Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem. 280:40195-200.
- Kumar S, Dodson GE, Trinh A, Puchalski JR, and Tibbetts RS. (2005). ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. Cell Cycle. 4:1667-74.
- Abraham RT and Tibbetts RS. (2005) Guiding ATM to broken DNA. Science. 308:510-511 (perspective).
- Brumbaugh KM, Otterness DM, Geisen G, Oliveira V, Brognard J, Li X, LeJeune F, Tibbetts RS, Maquat L, and Abraham RT. (2004). The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell. 14:585-98.
Check PubMed for other publications by Randal S. Tibbetts.
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