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- Current Students
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Student Publications
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Bae, JuYun
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Boehm, Bayli
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Boley, Patricia
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Bolterstein, Elyse
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Brody, Matthew
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Bultman, JoAnna
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Calkins, Marcus
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Desotelle, Josh
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Dever, Joe
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Hutchinson, John
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Jung, Brittney
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Mehta, Vatsal
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Novick, Rachel
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Pham, Ly
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shetty, Ameesha
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Tarapore, Rohinton
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Wiecinski, Paige
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Yang, Sarah
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Yu, Min
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Bolterstein, Elyse
Photo Credits: Chris Frazee, Media Solutions
 Elyse Bolterstein
PhD Candidate - Started 2004
Native of Rochester Hills, Michigan
Lab of B. Lynn Allen-Hoffmann, PhD
Contact Information
Email: Elyse Bolterstein
Undergraduate Work
University of Michigan
Bachelor of Science, Resource Ecology & Management (2002)
Research as of Spring 2007
The Aryl Hydrocarbon Receptor (AhR) and its dimerization partner, the Aryl Hydrocarbon Nuclear Translocator 1 (ARNT1) are PAS family proteins that are integral in sensing xenobiotic compounds, including the potent AhR ligand, TCDD. A characteristic dermatopathology resulting from environmental exposure to TCDD is chloracne, which exhibits aberrant keratinocyte lineage and differentiation patterns. My research will utilize a line of immortalized keratinocytes (NIKS) in both monolayer and organotypic cultures, to further investigate cellular roles of ARNT1 as potential mechanisms for chloracne development.
Previous work in our lab has shown that knockdown of ARNT1 in monolayer keratinocyte culture lead to an increase of the anti-microbial peptide, hBD-3. This was also true in TCDD-treated organotypic culture, which may suggest a role of ARNT1 in innate immune defense. Our next step will be the creation of a NIKS line expressing short-hairpin RNAs (shRNAs) specific to ANRT1, which will provide for a stable knockdown of the protein in order to directly investigate its role in human skin morphogenesis and dermatopathologies.
Funding
National Research Service Award Predoctoral Traineeship (NIEHS Training Grant T32, 02/2005-Present)
Posters
AhR pathway genes are expressed in human embryonic stem cells
Elyse A. Bolterstein1 and B. Lynn Allen-Hoffmann1,2
1Molecular and Environmental Toxicology Center and 2Department of Cellular and Molecular Pathology School of Medicine and Public Health - University of Wisconsin-Madison; Madison, Wisconsin, USA (Presented at 2008-SOT in Seattle, WA)
RNAI - Mechanisms and Tools for Toxic Control in Aspergillus Species. E. A. Bolterstein1 and N. P. Keller1,2
1Molecular and Environmental Toxicology, University of Wisconsin, Madison, WI
2Plant Pathology, University of Wisconsin, Madison, WI (Presented at 2006-SOT in San Diego)
 Interests/Hobbies
I like to spend a lot of my free time outdoors: biking, running, hiking, browsing the tasty things at the farmer’s market and snowshoeing when the weather gets too nasty to do the other things. My indoor hobbies include reading, cooking and teaching a UW spinning class a couple times a week. Although there are a couple Madison sports I’m completely into (Mallard’s baseball and Badger hockey), I’m a diehard Michigan football fan.
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