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- Current Students
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Student Resources
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Student Publications
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Bae, JuYun
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Boehm, Bayli
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Boley, Patricia
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Bolterstein, Elyse
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Booth, Clarissa
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Brody, Matthew
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Bultman, JoAnna
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Desotelle, Josh
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Elmergreen, Tammy
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Hutchinson, John
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Narae
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Lorch, Jeff
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Mehta, Vatsal
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Novick, Rachel
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Park, Heesoo
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Pham, Ly
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shanle, Erin
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Shetty, Ameesha
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Syed, Deeba
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Tarapore, Rohinton
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Wiecinski, Paige
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Wong, Letitia
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Dengler, Emelyne
Photo Credit: Chris Frazee, Media Solutions
 Emmie Dengler
PhD Candidate - Started 2005
Native of Horseheads, NY
Lab of Richard Peterson PhD
Contact Information
Email: Emmie Dengler
Undergraduate Work
Kenyon College
Bachelor of Science, Biology (2005)
Research as of August 2006
“Molecular mechanisms of decreased cardiomyocyte proliferation in dioxin exposed zebrafish embryos”
Our lab has previously shown that exposure of zebrafish embryos to TCDD causes cardiotoxicity, including decreased cardiac output, peripheral blood flow, and cardiomyocyte number. Additionally, microarray experiments show that TCDD exposure causes significant changes in gene expression in the heart. Genes that are misregulated by TCDD are involved in metabolism, contractility, and heart development; many of the genes down regulated at later time points are involved in cellular proliferation, which correlates temporally with the observed decrease in cardiomyocyte number. One focus of my project is to determine whether the decrease in cardiomyocyte number is related to a decrease in cardiomyocyte proliferation and to discern the molecular mechanisms underlying this effect.
Interests/Hobbies
Bicycling, rock climbing, hiking, camping, just being outside in general, reading, cooking
Funding
National Research Service Award Predoctoral Traineeship (NIEHS Training Grant T32, 02/2006-present)
Publications
Lavine, JA, AJ Rowatt, T Klimova, AJ Whitington, E Dengler, C Beck, and WH Powell. (2005) Aryl Hydrocarbon Receptors in the frog Xenopus laevis: Two AHR1 paralogs exhibit low affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Sci. 88:62-70.
Posters
Lipinski, RJ, E Dengler, WH Heideman, RE Peterson, W Bushman. Dietary alkaloids affect human sonic hedgehog signaling. Society of Toxicology, San Diego, CA, March, 2006.
Philips, BH, E Dengler, TC Susman, and WH Powell. Mechanisms of dioxin insensitivity vary during development of the frog Xenopus laevis. Thirteenth International Symposium on Pollution Responses in Marine Organisms (PRIMO13), Alessandria, Italy, June 2005.
Dengler, E, BH Philips, TC Susman, AJ Rowatt, and WH Powell. Aryl hydrocarbon receptor expression precedes CYP1A inducibility by dioxin during Xenopus laevis development. Society for Environmental Toxicology and Chemistry, Portland, OR, November 2004.
L Stancik, D Stancik, LM Mauer, DM Barnhart, EK Dengler, Y Yoncheva, B Schmidt, JL Slonczewski. pH Regulates Periplasmic Proteins and Amino Acid Catabolism in Escherichia coli. 102nd Annual Meeting of the American Society for Microbiology, Salt Lake City, Utah, May, 2002
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