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Bae, JuYun
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Boehm, Bayli
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Boley, Patricia
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Bolterstein, Elyse
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Booth, Clarissa
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Brody, Matthew
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Bultman, JoAnna
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Desotelle, Josh
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Elmergreen, Tammy
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Hutchinson, John
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Narae
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Lorch, Jeff
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Mehta, Vatsal
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Novick, Rachel
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Park, Heesoo
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Pham, Ly
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shanle, Erin
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Shetty, Ameesha
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Syed, Deeba
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Tarapore, Rohinton
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Wiecinski, Paige
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Wong, Letitia
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Dever, Joe
 Joe Dever - Email
PhD 2008 (Started 2003)
Native of Kansas City, MO
Lab of Adnan Elfarra, PhD
Undergraduate Work
Luther College
Bachelor of Science, Biology (2001)
Memberships
American Society for Pharmacology and Experimental Therapeutics
Interests/Hobbies
I love playing and listening to music of all forms. In particular, my
wife (Ann) and I are the church musicians at Primrose Lutheran, a 150
year old rural church (She directs the choirs and I play the piano and
organ for the services). We're expecting our first child next April.
 Funding
National Research Service Award Predoctoral Traineeship (NIEHS Training Grant T32, 05/05-present)
Research as of August 2006
The goal of my research is to determine the role of flavin-containing monooxygenases (FMOs) in methionine (Met) metabolism and toxicity. FMOs are membrane-bound enzymes that catalyze the oxidation of a variety of sulphur, nitrogen, and phosphorous-containing drugs and xenobiotics. FMO1-4 oxidize Met to methionine sulfoxide (MetO). FMO3, the primary isoform expressed in adult human liver, has the lowest Km and favors methionine-d-sulfoxide (Met-d-O) formation over methionine-l-sulfoxide (Met-l-O). Because female mice, but not males, also express FMO3 in the liver, mice are an appropriate model for studying this enzyme.
Publications
Dever JT, Elfarra AA - L-Methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: Gender differences and inhibition with aminooxyacetic acid. Drug Metab Dispos. 2008 Aug 7. [Epub ahead of print]
Dever JT, Elfarra AA - L-Methionine Toxicity in Freshly-Isolated Mouse Hepatocytes is Gender-Dependent and Mediated in Part by Transamination. J Pharmacol Exp Ther. 2008 Jun 13. [Epub ahead of print]
Dever JT and Elfarra AA (2006) In Vivo Metabolism of L-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites. Drug Metab Dispos, Accepted September 8, 2006 (in press) .
Posters
Dever, JT and Elfarra AA (2006) Evidence for the involvement of flavin-containing monooxygenase 3 in the in vivo S-oxidation of L-methionine in female mice. 2006 Experimental Biology meeting abstracts. The FASEB Journal, 20, Abstract #177.7
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