|
- Current Students
|
|
Student Resources
|
|
Student Publications
|
|
Bae, JuYun
|
|
Boehm, Bayli
|
|
Boley, Patricia
|
|
Bolterstein, Elyse
|
|
Booth, Clarissa
|
|
Brody, Matthew
|
|
Bultman, JoAnna
|
|
Desotelle, Josh
|
|
Elmergreen, Tammy
|
|
Hutchinson, John
|
|
Irving, Amy
|
|
Irving, Roy
|
|
Johnson, Brian
|
|
Johnson, Delinda
|
|
Jung-Hynes, Brittney
|
|
Kumar, Kartik
|
|
Lee, Narae
|
|
Lorch, Jeff
|
|
Mehta, Vatsal
|
|
Novick, Rachel
|
|
Park, Heesoo
|
|
Pham, Ly
|
|
Rhoads, Keelia
|
|
Rufer, Echoleah
|
|
Sand, Jordan
|
|
Schmit, Travis
|
|
Shan, Weihua
|
|
Shanle, Erin
|
|
Shetty, Ameesha
|
|
Syed, Deeba
|
|
Tarapore, Rohinton
|
|
Wiecinski, Paige
|
|
Wong, Letitia
|
|
Yang, Sarah
|
|
Yu, Min
|
|
Zhao, Yun
|
|
Calkins, Marcus
|
|
|
|
|
|
Feld, Mara
 Mara Feld - Email
PhD 2008
Native of Carbondale, IL
Lab of Norman Drinkwater, PhD
Undergraduate Work
Skidmore College, Saratoga Springs, NY
BA, Chemistry (1998)
Work Exerience
Department of Molecular Biology, Princeton University, Princeton, NJ
Laboratory Technician 1998-1999
Research as of May 2007
Males are much more susceptible than females to hepatocellular carcinoma development. The mouse has been a useful model for understanding these differences. Intact females have reduced tumor multiplicity compared to ovariectomized females. Estrogen has been suggested to be responsible for this protection against liver tumor development. The purpose of these studies is to understand how estrogen influences hepatic gene expression in the C57BL/6J mouse. We are also interested in the role of estrogen receptor-alpha and estrogen receptor-beta in regulating hepatic gene transcription. We have found that estrogen receptor-alpha, but not -beta, is critical in protection against DEN-initiated hepatocarcinogenesis. Since female mice are known to be less susceptible than male mice to development of liver tumors, it was surprising when the National Toxicology Program found that, out of 112 hepatocarcinogens tested, 21 were more hepatocarcinogenic in females than males, and 34 were active in females only. A second set of studies, that we have conducted, look at the effects of the female-specific hepatocarcinogens, safrole, fumonisin B1, and 5,5-diphenylhydantoin, in regulating hepatic gene expression. Humans are exposed to safrole by consumption of spices, such as sassafras, sweet basil and cinnamon. Fumonisin B1 is a mycotoxin and humans are mainly exposed by consumption of contaminated corn products. 5,5-diphenylhydantoin is used clinically as an antiepileptic drug and is known to be teratogenic and associated with lymphoma. Our studies use a toxicogenomics approach to examine the mechanisms of these female-specific hepatocarcinogens in the C57BL/6J mouse model. It is hypothesized that the estrogen-dependent protective pathways will be disrupted by female-specific hepatocarcinogen treatment.
Memberships
2007-present Society of Toxicology
2007-present Society of Environmental Toxicology and Chemistry
2007-present Graduate Women in Science
1998-present American Chemical Society
Interests/Hobbies
Horseback Riding, Hiking, Outdoor Activities
Awards
2007 Vilas Travel Grant Award, University of Wisconsin, Madison, WI
Posters- Society of Environmental Toxicology and Chemistry (SETAC), Milwaukee, WI, November 11-15, 2007
- Midwest Regional Chapter-Society of Toxicology, Concordia University Wisconsin, November 2, 2007
- Nanotoxicology, Midwest Regional Chapter, Society of Toxicology, Lincolnshire Il, 18 May 2007.
- Frontiers of Pharmacology and Toxicology, Chicago, 26-31 August, 2006.
Meetings Attended
Poster at the Society of Environmental Toxicology and Chemistry (SETAC) North America 28th Annual Meeting, Urban Environmental Issues: Impacts on Ecological Systems, November 2007, Milwaukee, WI.
Attended the Midwest Regional Chapter, Society of Toxicology, 26th Annual Meeting, Forensic Toxicology, November 2007, Concordia University Wisconsin.
Poster at the Midwest Regional Chapter, Society of Toxicology, 25th Annual Meeting, Nanotoxicology, May 2007, Lincolnshire, Il.
Poster at the International Conference: Frontiers of Pharmacology and Toxicology, August 2006,
Chicago, Il. Abstracts / Chemico-Biological Interactions 161(3) 221.
Talk at the Eastern New York Section of the American Chemical Society Research Symposium, April 1998, Saratoga Springs, NY.
|
|
|
|
