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- Current Students
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Student Publications
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Bae, JuYun
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Boehm, Bayli
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Boley, Patricia
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Bolterstein, Elyse
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Brody, Matthew
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Bultman, JoAnna
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Calkins, Marcus
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Desotelle, Josh
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Dever, Joe
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Feld, Mara
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Hutchinson, John
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Jung, Brittney
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Klingbiel, Sarah
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Mehta, Vatsal
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Novick, Rachel
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Pham, Ly
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shetty, Ameesha
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Tarapore, Rohinton
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Wiecinski, Paige
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Yu, Min
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Gao, Na
 Na Gao
Masters - Started 2005 - Graduated Spring 2008
Native of China
Lab of Jaehyuk Yu
Contact Information
Email: Na Gao
Undergraduate and Graduate Work
Peking University Health Sciences Center (1997-2004)
Masters of ScienceGastroenterology, Internal Medicine (2004)
Bachelors of Science, Medicine (2002)
Research as of Spring 2008
My research focuses on the identification and characterization of the genes controlling the growth and development of Aspergillus nidulans. My current project is to characterize the osaA (Orchestrator of Sexual and Asexual development) gene that was identified in our lab from a screening for repressors of conidiation. The OsaA protein contains a TOS9 domain, and its homologue in Candida albicans, Wor1, has been found to play important roles in the white-opaque switch which is crucial for mating in C. albicans. The deletion of the osaA gene in A. nidulans caused hyper-active sexual development and less productive asexual sporulation compared to the wild type. The overexpression of osaA caused a fluffy phenotype in the first two days of incubation and delayed asexual sporulation. I hypothesized that OsaA is a regulator of the balance of sexual and asexual development in Aspergillus nidulans. I am using various methods including yeast-two-hybrid, Northern blot and ChIP-chip to find the possible interacting genes of osaA and how osaA affects the expression of other known genes involved in the growth and development of A. nidulans. The deletion mutants of the osaA homologue in the opportunistic human pathogen Aspergillus fumigatus were also constructed and the phenotype will be further studied.
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