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- Current Students
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Student Publications
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Bae, JuYun
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Boehm, Bayli
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Boley, Patricia
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Bolterstein, Elyse
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Brody, Matthew
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Bultman, JoAnna
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Calkins, Marcus
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Desotelle, Josh
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Dever, Joe
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Feld, Mara
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Hutchinson, John
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Jung, Brittney
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Klingbiel, Sarah
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Mehta, Vatsal
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Novick, Rachel
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Pham, Ly
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shetty, Ameesha
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Tarapore, Rohinton
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Wiecinski, Paige
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Yu, Min
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Novick, Rachel
 Rachel Novick
PhD Candidate - Started
Native of Massachusetts
Lab of Adnan Elfarra, PhD
Contact Information
Email: Rachel Novick
President of METC Student Liaison Committee (2007-08)
Undergraduate Work
Washington University in St. Louis (1998-2002)
B.A. Biology
B.A. Environmental Science
Research
Flavin-containing monooxygenases (FMOs) are a family of microsomal proteins that catalyze the oxidation of many pharmaceutical drugs, pesticides, and endogenous compounds. Generally, FMO oxidation aids in excretion and detoxification; however, some substrates may be bioactivated to more reactive metabolites. In humans, five expressed FMO isoforms (FMO 1-5) and six non-expressed pseudogenes (FMO6P-11P) have been detected. Each FMO isoform exhibits distinct substrate specificity and sex-, tissue-, age-, and species-dependent expression patterns. My research focuses on FMO localization and characterization in rat liver and kidney. Currently, I am working to purify FMO3 and FMO4 from rat tissues in order to characterize their immunological and enzymatic properties. FMO3 was purified from male rat kidneys and was identified by SDS-PAGE and mass spectral analysis. The kinetic parameters (Km, Vmax) of rat renal FMO3 were determined with several FMO substrates. The characterization of FMOs from rat tissues may help elucidate their role in xenobiotic metabolism.
 Funding
National Research Service Award Predoctoral Traineeship (NIEHS Training Grant T32, Feb 2005-2008)
Memberships
Society of Toxicology (2008)
Posters
Purification and Characterization of FMO3 from Male Rat Kidneys. Rachel Novick and Adnan Elfarra Society of Toxicology 2008 Meeting - Seattle, WAHobbies/Interests
Hiking, jogging when I'm motivated, camping trips, skiing (downhill, cross-country, and water), pick-up sports wen the weather is nice, and reading. I would love to do more traveling and went on a great trip to Cozumel Spring 2006 to relax and snorkel the reefs. I also enjoy movies, shopping, card games, and embarrassingly reading celebrity gossip online.
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