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Bae, JuYun
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Boehm, Bayli
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Boley, Patricia
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Bolterstein, Elyse
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Booth, Clarissa
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Brody, Matthew
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Bultman, JoAnna
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Desotelle, Josh
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Elmergreen, Tammy
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Hutchinson, John
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Irving, Amy
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Irving, Roy
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Johnson, Brian
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Johnson, Delinda
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Jung-Hynes, Brittney
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Kumar, Kartik
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Lee, Narae
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Lorch, Jeff
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Mehta, Vatsal
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Novick, Rachel
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Park, Heesoo
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Pham, Ly
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Rhoads, Keelia
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Rufer, Echoleah
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Sand, Jordan
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Schmit, Travis
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Shan, Weihua
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Shanle, Erin
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Shetty, Ameesha
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Syed, Deeba
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Tarapore, Rohinton
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Wiecinski, Paige
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Wong, Letitia
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Yang, Sarah
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Yu, Min
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Zhao, Yun
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Calkins, Marcus
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Tarapore, Rohinton
 Rohinton Tarapore - Email
PhD Candidate - Started 2005
Hails from Bombay, India
Lab of Hasan Mukhtar, PhD
Undergraduate and Graduate Work
Wayne State University, MI (2002-2004)
Masters of Science (Biological) (2004)
University of Mumbai, India (1998-2000)
Masters of Science-Zoology specializing in Physiology (2000)
St. Xavier's College, Mumbai, India (1995-1998)
Bachelors of Science, Zoology & Biochemistry (1998)
Memberships
Smithsonian Society
National Geographic Society
Univ. of WI - Stem Cell & Regenerative Medicine Center (UW-SCMRC)
Interests/Hobbies
Discussing science, traveling, experiencing the outdoors, biking, whitewater rafting
Research as of Spring 2008
In the absence of Wnt, beta-catenin is recruited into a destruction complex leading to its ubiquitination and degradation by the proteosomes. The on-state of Wnt signaling results in post-translational stability by degradation of this complex. Accumulation of beta-catenin in the nucleus activates transcription of beta-catenin/TCF target genes. Our lab recently found a target gene for beta-catenin namely CRD-BP. This CRD-BP binds and stabilizes mRNA of several genes (including c-myc and b-TrCP). Studies have shown that a third of the melanomas have upregulated Wnt expression and NF-kB is activated in most epithelial tumors. My immediate aim is to assess the role of CRD-BP in melanoma development. To this end, I am planning to analyze the expression of CRD-BP in primary tumorigenic properties of melanoma cell lines.
My research also includes the study of a chemopreventive agent Lupeol and its effect on melanomas. We plan to expose various melanoma cell lines to this agent and study the expression of CRD-BP and various other proteins.
Publications
Elcheva I, Tarapore RS, Bhatia N, Spiegelman VS, Overexpression of mRNA-binding protein CRD-BP in malignant melanomas. Oncogene. 2008 May 5. [Epub ahead of print]
Simultaneous administration of diethylphthalate and ethyl alcohol and its toxicity in male Sprague-Dawley rats. Toxicology. 2000 May 19;147(1):23-31
Posters
Overexpression of mRNA binding protein CRD-BP in malignant melanomas - R. Tarapore, I. Elcheva, N. Bhatia and V. Spiegelman. University of Wisconsin Comprehensive Cancer Center (UWCCC) research retreat (February 2008).
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