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Research Milestones
2007- MERIT R37 - Susan Smith
Smith's research into the molecular mechanisms underlying alcohol's damage to the fetus was awarded the MERIT designation by the National Institutes of Health in August 2007. The MERIT R37 recognizes research of especial significance and originality.
2005 - Accelerated Aging - Tomas A. Prolla
Understanding mechanism of accelerated aging. Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging. Science 2005 Jul; 309:481-484.
2005 Nrf2 - Jeffrey A. Johnson Lab
Description of molecular mechanism by which transcription factor Nrf2, bound to the promoter sequence ARE (antioxidant responsive element) protects different cell types, providing therapeutic potential in prevention of carcinogenesis and neurodegenerative diseases. Title: Protection from mitrochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci 2005 Jan 4; 102(1):244-9. Nrf2, a multi-organ protector? FASEB J 2005 July; 19(9):1061-1066.
2004-Dioxin/Prostate Development - Labs of Ralph M. Albrecht and Richard E. Peterson Observation of how dioxin inhibits prostate development. Title:2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits prostatic epithelial bud formation by acting directly on the urogenital sinus. J Urol. 2004 Jul; 172(1):365-368.
2004-Green Tea/Prostate Cancer - Labs of Nihal Ahmad and Hasan Mukthar
Demonstration that drinking green tea inhibits prostate cancer growth. Title: Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I-Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer. Cancer Res 2004 Dec; 64:8715-8722.
2002-MERIT R37 - Christopher A. Bradfield
Understanding the significance and role of the family of transcriptional regulators known as PAS proteins, which control a number of processes including xenobiotic metabolism, circadian rhythms, angiogenesis, and neurogenesis
2000-MERIT R37 - Richard E. Peterson
Research on the developmental reproductive toxicity of TCDD
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