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Hannam, Paul
Publications
Publications
Lipinski, R.J., Hutson, P.R., Hannam, P.W., Nydza, R.J., Washington, I.M., Moore, R.W., Girdaukas, G.G., Peterson, R.E. and Bushman, W.: Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the Hedgehog signaling antagonist cyclopamine in the mouse. Toxicol. Sci. 104: 189-197, 2008.
Photo Credit: Chris Frazee, Media Solutions
 Hails from Greenbelt, Maryland.
Fall 2007 will be a Senior at High Point University in North Carolina majoring in Biology
Paul has been interested in medical and scientific research/development from a very young age. After high school graduation (1998) he joined the U.S. Navy as a hospital corpsman. He did anything from drawing blood to immunizations, record keeping, labor and delivery assistance to field medic in Iraq. When his contract with the Navy was up he returned to school and is currently pursuing a bachelors degree of science in biology with a minor in chemistry @ High Point University in North Carolina. He is particularly interested in genetic research as well as infectious organisms.
 
Left: Paul working in Wade Bushman lab @ UW-Madison- School of Medicine and Public Health - Department of Urology
Photo Credit: Chris Frazee, Media Solutions
Right: Paul with his mentor Rob Lipinski
Reason I chose UW-Madison Molecular and Environmental Toxicology Summer Research Program
At my school, at least in the science department, summer research is highly encouraged. High Point University, being such a small school of about 3000, you know the faces and names of almost everybody including the department chairs and the president of the school. It so happened that my advisor, who is also the chair of biology department, let me know that summer research is very much favored when applying to professional and graduate programs.
I applied to about 6 different programs, and I remember being impressed with the UW's application form because they made it so easy to apply. I didn't have to fill out three different applications for the three programs of my choice. All I had to do was fill out one application and choose my three. Then my transcript could be loaded-up right there. I didn't have to worry about it being official. I received a return phone call from Dr Czuprynski, here at the UW-Madison Molecular and Environmental Toxicology program within 2 weeks of me applying. I thought that was just amazing. This was one of the universities that responded to me first and the stipend was very competitive compared to the others. I was also approved by a couple other programs but they responded late and/or the stipend was not as compelling.
I have learned a lot since I have been here and the program has opened my eyes to the rigors of research. I think the experience that I have gained is invaluable and will be with me for years to come. So far I have not regretted my decision and I am looking forward to analyzing my data and giving my presentation. I am so excited about this, now I just have to make everyone else see why I am so excited so they can become excited with me.
Funding
Participating in the Molecular and Environmental Toxicology Summer Research Opportunity Program through the funding of the National Institute of Health.
 Title of Summer Research
Pharmacokinetics of the Hedgehog Signaling Inhibitor Cyclopamine
This summer was an invaluable experience for me. I had the wonderful opportunity of doing research first hand. I see what it means to be both a consumer and a producer. My project was on the pharmacokinetics of cyclopamine in mice. The aim of the study to was establish a favorable route of drug administration that will give a desired broad theraputic window, while maximizing area under the curve and minimizing animal death. We use three different methods of administration; The Intra-peritoneal injection, the oral gavage (by mouth), and the micro-osmotic pump. After analysis of the date acquired from the study we found that the osmotic pump was the most favorable to give us our broad therapeutic window, with the highest area under the curve and a low mortality level.
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