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SROP Trainers
Allen-Hoffmann, B. Lynn - Professor, School of Medicine and Public Health, Pathology & Laboratory Medicine. Affiliated with METC since 1989. TRAINER and Deputy PI on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Epithelial Differentiation and Carcinogenesis. Discovered and characterized mechanism of Ah receptor activations affected by disruption of cell adhesion. Role of Ah rceptor and other bHLH-PAS family members in development and xenobiotic induced pathogensis of human stratified squamous epithelia. Tissue engineered human models for toxicity testing. Advisor to METC Graduate Students: Nadira DeAbrew (current), Lisa VanPay (2006), Jenniver Loertscher (2001), Kris Sachsenmeler (2001), Christine Sadek (1995) Mentor to METC Post-Docs: Lori White (1996-1997)
Albrecht, Ralph M. - Professor, College of Agriculture and Life Sciences, Animal Sciences. Affiliated with METC since 1976. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Organophosphate Immunoactivity. Biocompatibility. Imaging. Microscopy. Effects of toxicants on structure and function of immunoactive cells and on regulatory mechanisms influencing immune responses. Biocompatibility; biological responses to artificial materials used to repair or replace tissues and organs. Mentor to Past METC SROP Participants: Angel Navarro-Zayas (2000) and Rublin Santiago-Lugo (2000) Mentor to METC Post-Docs: Linda Lutz (1989-1990)
Bradfield, Christopher A.- PhD, Director, METC, Professor of Oncology School of Medicine and Public Health. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Signal Transduction of PAS proteins. Mechanisms of environmental sensing, e.g., pollution, hypoxia and light. Application of mouse and yeast genetics to understand toxicant signal transduction pathways. Toxicology of dioxins, PCBs and PAHs by Ah receptor and ARNT. Regulation of xenobiotic metabolism. Developmental toxicology. Advisor to METC Graduate Students: Maureen Bunger (2001) Mentor to METC Post-Docs: Suzanne Williams (2004-2006), John La Pres (1997-1998)
Bushman, Wade - Associate Professor, School of Medicine and Public Health, Surgery. Affiliated with METC since 2002. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Human Development/ Teratogenicity. Prostate. Sonic Hedgehog. BMP-4. Inhibition of tumor growth by cyclopamine, and Shh signaling as a therapeutic target in prostate cancer. Mentor to Past METC SROP Participant: Robert Nydza Advisor to METC Graduate Students: Rob Lipinski (current) and Min Yu (current). Mentor to METC Post-Docs: Travis Jerde (2006-2007)
Cook, Mark E. - Professor, College of Agriculture and Life Sciences, Animal Sciences. Affiliated with METC since 1987. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Conjugated Linoleic Acid. Immunity. Inflammation. Cytokines. Cachexia. Lipids. Mode of action in chemicals, heavy metals, and nutrients in metabolism, immunity and disease. Mentor to Past METC SROP Participants: Joel Gonzalez Toledo (2006), Victor Alos (2005) Advisor to METC Graduate Students: Guangming Li (2005), Danielle Devoney (1999), Natalie DiNicola (1995)
Czuprynski, Charles J. - Professor, School of Veterinary Medicine, Pathobiological Sciences. Affiliated with METC since 1990. TRAINER and PI on the METC NIEHS Short-Term Research Training for Minority Students Grant. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Investigating interactions amongst stromal cells, cytokines, and progenitor cells in disruption of hematopoiesis by PAHs. Also studies the effects of bacterial leukotoxins and endotoxin on leukocytes and endothelial cells. Investigating the importance of the AhR in innate immunity to bacterial infection. Mentor to Past METC SROP Participants: Burnell P. Brunious (2001) Advisor to METC Graduate Students: Shawn Heidel (1999) and Paul Stevens (Masters-1995)
Elfarra, Adnan A. - Professor of Toxicology, Department of Comparative Biosciences, School of Veterinary Medicine, School of Pharmacy. Affiliated with METC since 1987. Bioactivation; Cellular and Molecular Basis for Toxicity and Target Organ Selectivity; Biomarkers of Exposure and Effects. TRAINER and PI on Pre- and Post Doctoral Training Grant. Deputy PI and TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Cellular and Genetic Toxicology. Toxicant and carcinogen metabolism. Mechanisms of toxicity and target organ selectivity. DNA and hemoglobin modifications. Toxicity of the industrial chemicals trichloroethylene, tetrachloroethylene, 1,3-butadiene, and related compounds. Advisor to METC Graduate Students: Joe Dever (current) and Rachel Novick (current), Christopher Sprague (2004), Sjofn Gunnarsdottir (2002), Sharon Ripp (1998), Rebecca Selzer (1997), Jane Sharer (1993), Peter Sausen (1992), In Young Hwang (1992), and Renee Krause (1992).
Gould, Michael N. - Professor, School of Medicine and Public Health. Affiliated with METC since 1979. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Molecular Biology of Breast Cancer. Identification of genes that prevent breast cancer. Signaling pathway differences between H-Ras and K-Ras oncogenes and role in organ-specific carcinogenesis. Molecular basis of selective cell death and proliferation inhibition through study of effects of monoterpene drugs and other potential chemoprotective agents. Breast cancer risk assessment by surrogate biomarkers. Advisor to METC Graduate Students: Tai Yu-Tzu (1996), Sandra Eldridge (1988), Jennifer Ariazi (2003), Mentor to METC post-doc: Michele Cotroneo (2004), Lauri Shepel (1991-1992), Lisa Seidman (1985-1986)
Heideman, Warren - Professor, School of Pharmacy. Affiliated with METC since 1997. Cellular and Genetic Toxicology. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Regulation of yeast cell cycle by signal transduction pathways. Developmental toxicology of TCDD in zebrafish. Mentor to Past METC SROP Participants: Chasity Phillips (2003) Advisor to METC Graduate Students: Dagmara Antkiewicz (current) Vatsal Mehta (current), Bing Liu (1996)
Hickey, William J. - Professor, College of Agriculture and Life Sciences, Soil Science. Affiliated with METC since 1990. Associate Director of METC graduate program. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Bioavailability of Agents in Remediation. Bacterial metabolism of xenobiotics. Bioremediation of contaminated soil and groundwater. Use of nucleic acid probes to study microbial populations in soil and groundwater. Mentor to Past METC SROP Participants: LyLy Pham (2006), Ileana Rivera (2005), and Elizabeth Padilla (2003)Advisor to METC Graduate Students: Scott Arnold (1995), Alice Yuroff (2002), Michele Zwolinski (2001), Emily Burton (Masters 2004), Ameesha Shetty (current)
Jarrard, David F. - Associate Professor, School of Medicine and Public Health, Surgery, Urology. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Prostate Cancer. Oxidative Stress. Insulin-Like Growth Factor II. DNA methylation in cancer development Molecular genetics of prostate cancer. Mentor to Past SROP Participants: Malije Onwueme (2003) and Carol Sandefur (2002) Advisor to METC Graduate Students: J. Lea Roberts (2007), Josh Desotelle (current)
Jefcoate, Colin R. - Professor, School of Medicine and Public Health, Molecular and Cellular Pharmacology. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre- and Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Roles of cytochrome P4501B1 and Ah Receptor in fat pad development, bone marrow toxicity and carcinogenesis in susceptible mouse strains (intestines, prostate, and mammary gland). Effects of polycyclic aromatic hydrocarbons and PCBs in these processes Molecular mechanism of cholesterol conversion to steroid hormones. Effects of obesity and steroid synthesis and carcinogenesis. Mentor to Past METC SROP Participants: Donnia Alexander Advisor to METC Graduate Students: Melissa Cimafranca, Ph.D. (2006), Noe Galvan (2004), Paul Hanlon (2003), David Alexander (1999), Leo Ganem (1999), Paul Brake (1997), Michael Dibartolomeis Jr (1984) Mentor to METC Post-Docs: Sakina Eltom (1996), Shelley Larsen-Su (1999), Craig Marcus (1983-1984), Maro Christou (1984 & 1986)
Johnson, Jeffrey A. - Associate Professor, School of Pharmacy. Affiliated with METC since 1999. (METC Alumni 1992) TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Alzheimer's. Amyotrophic Lateral Sclerosis. Huntington's. Parkinson's. Autoimmune Disease. Molecular mechanism of tert-butylhydroquinone (tBHQ) activation of Antioxidant Response Element-driven genes in neuroblastoma cells, primary neuronal and glial cultures, and in vivo. How ARE-driven genes block cell death. Effect of overexpression of amyloid precursor protein on the ARE and antioxidant genes in neurons and glia. Mentor to Past METC SROP Participant: Sean Redd (2002) Advisor to METC Graduate Students: Marcus Calkins (current), Jong-Min Lee (2003), Mentor to METC Post-Docs: Jon Kern (2004), Julie Kern (2004)
Keller, Nancy P. - Professor, College of Agriculture and Life Sciences, Plant Pathology. Affiliated with METC since 2002. Host-Fungal Interactions. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Molecular genetics of mycotoxin biosynthesis; fungal development; host-fungal interactions leading to toxin production and sporulation. Mentor to METC Post-Docs: Marion Brodhagen (2006)
Peterson, Richard E. - Professor, School of Pharmacy. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. AhR Signaling. Reproductive and Developmental Toxicology. Mouse and zebrafish, Dioxin (TCDD), Prostate Growth, Develoment and Cancer, Heart Development, Nanotoxicology. Mentor to Past METC SROP Participants: Changelle Gandy (2002) Advisor to METC Graduate Students: Sarah Allgeier (current), Emmie Dengler (current), Sara Carney (2005), Amy Prasch ( 2004), Eric Andreasen (2001), Christian Abnet (1998), Michael Hornung (1998), James Kleeman (1998), Beth Roman (1997), Erick Zabel (1995), Jack VandenHeuvel (1991), and mark Seefeld (1982). Mentor to METC Post-Docs: Wayne Fritz (2003), Carl Potter (1982-1983), Mary Vomachka (1984-1985), Shahanara Saroya (1991-1992), Robert Tangauy (1996-1997), Tisha King-Heiden (2006-present), Susan Bello (2000-2001)
Prolla, Tomas A. - Associate Professor, School of Medicine and Public Health, Genetics. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. DNA Repair. Cancer. Aging. Generation of animal models of human cancer syndromes using gene targeting in the mouse. Role of DNA repair in spontaneous and induced mutagenesis. Signal transduction pathways involved in DNA repair. Mentor to Past METC SROP Participants: David Macias Jr. (2003) Advisor to METC Graduate Students: Cheol-Koo Lee (2002)
Sandgren, Eric P. - Associate Professor, School of Veterinary Medicine, Pathogiological Sciences. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Genetic and Extracellular Regulation of Tissue Growth. Molecular mechanisms of carcinogenesis; transgenic mouse models of cancer genetics. Studies of xenogeneic transplantation and human hepatocyte biology in rodents. Advisor to METC Graduate Students: Patricia Boley (current) Mentor to METC Post-Docs: Teresa Rose-Hellekant (1997-1998)
Schuler, Linda A. - Professor, School of Veterinary Medicine, Comparative Biosciences. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Hormonal Effects in Breast Cancer and Human Development. Prolactin and related hormones' receptors, signaling and processing; cell specific actions on maternal and fetal tissues, and role in mammary cancer. Mentor to Past METC SROP Participant: Mallory Willkom (2005) Advisor to METC Graduate Students: Jennifer Gutzman (2004)
Sheibani, Nader - Associate Professor, School of Medicine and Public Health, Ophthalmology & Visual Science. Affiliated with METC since 2001. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. and Short-Term Research Minority Training Grant. Vascular Biology. Regulation of angiogenesis, cellular adhesive mechanisms, focal adhesion and integrin signal transduction, pathological neovascularization and eye diseases. Mentor to Past METC SROP Participants: Tiffany M. Griffin (2006), and Jeremey Sturgill (2005)
Smith, Susan M. - Professor, College of Agriculture and Life Sciences, Nutritional Science. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Human Development and Risk. Fetal Alcohol Syndrome. Retinoids. Trichloroethylene. Molecular mechanism underlying alcohol-related birth defects (ethanol-dependent signal transduction and Ca2+ transients in triggering neuronal apoptosis). Retinoid action in fetus and adult, with emphasis on vitamin A status and heart function. Risk and mechaism underlying trichloroethylene-induced cardiac defects. Advisor to METC Graduate Students: Echoleah Rufer (current), Fernandez Cavieres (2001), Katherine Kragtorp (2003), Evan Thackaberry (2002)
Trepanier, Lauren A. - Associate Professor, School of Veterinary Medicine, Medical Sciences. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Drug Hypersensitivity. HIV. Drug Detoxification. Cytochrome b5 Reductase. Genetic and biochemical variability in drug metabolism and its relationship to adverse drug reactions and drug toxicity. Arylamines, nitroso compound and hydroxylamines. Sulfonamide drug hypersensitivity in AIDS patients. Therapeutic drug monitoring for veterinary patients. Advisor to METC Graduate Students: Keelia Rhoads (current), and Joe Kurian (2006)
Wilding, George - Professor, School of Medicine and Public Health, Comprehensive Cancer Center. Prostate Cancer. Affiliated with METC since1989. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Prostate carcinogenesis; steroid and growth factor mediated growth control mechanisms; mechanisms of action of cytotoxic agents; drug resistance (chemotherapy agents). Advisor to METC Graduate Students: Elyse Lee (2005), Maureen Ripple (1996),
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