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Trainers-Current
The following faculty are listed as trainers on the competitive renewal application which was submitted in May 2007.
AHMAD, Nihal, PhD - Associate Professor, School of Medicine and Public Health, Dermatology. Affiliated with METC since 2003. Prostate, Breast and Skin Carcinogenesis. Tumor Promotion/Prevention. Molecular mechanism of UV-mediated carcinogenesis; signal transduction (especially regulation of cell cycle and apoptosis) in tumor promotion and prevention. Advisor to METC Graduate Students: Brittney Jung (current), Travis Schmit (current)
ALLEN-HOFFMANN, B. Lynn, PhD - Professor, School of Medicine and Public Health, Pathology & Laboratory Medicine. Affiliated with METC since 1989. TRAINER and Deputy PI on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Epithelial Differentiation and Carcinogenesis. Discovered and characterized mechanism of Ah receptor activations affected by disruption of cell adhesion. Role of Ah receptor and other bHLH-PAS family members in development and xenobiotic induced pathogenesis of human stratified squamous epithelia. Tissue engineered human models for toxicity testing. Advisor to METC Graduate Students: Elyse Bolterstein (current), Nadira DeAbrew (2007), Lisa VanPay (2006), Jennifer Loertscher (2001), Kris Sachsenmeler (2001), Christine Sadek (1995), Mentor to METC Post-Docs: Lori White (1996-1997)
BJORLING, Dale, DVM - Professor, School of Veterinary Medicine TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Inflammation of the bladder due to non-infectious causes; control of smooth muscle tone by neuropeptides. Roles of environmental estrogenic compounds in bladder disorders, including malignant transformation of bladder epithelial cells. General Surgery: primarily the urinary tract, thorax, biliary tract.
BRADFIELD, Christopher A. - Director, METC, Professor of Oncology School of Medicine and Public Health. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Signal Transduction of PAS proteins. Mechanisms of environmental sensing, e.g., pollution, hypoxia and light. Application of mouse and yeast genetics to understand toxicant signal transduction pathways. Toxicology of dioxins, PCBs and PAHs by Ah receptor and ARNT. Regulation of xenobiotic metabolism. Developmental toxicology. Advisor to METC Graduate Students: Brian Johnson (current), Maureen Bunger (2001) Mentor to METC Post-Docs: Erin Hsu (2007-2008), Suzanne Williams (2004-2006), John La Pres (1997-1998)
BUSHMAN, Wade, MD, PhD - Associate Professor, School of Medicine and Public Health, Surgery. Affiliated with METC since 2002. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Human Development/ Teratogenicity. Prostate. Sonic Hedgehog. BMP-4. Inhibition of tumor growth by cyclopamine, and Shh signaling as a therapeutic target in prostate cancer. Advisor to METC Graduate Students: Bayli Boehm (current), Min Yu (current), Rob Lipinski (2008) - Mentor to METC Post-Docs: Travis Jerde (2006-2007)
CZUPRYNSKI, Charles J, PhD - Professor, School of Veterinary Medicine, Pathobiological Sciences. Affiliated with METC since 1990. TRAINER and PI on the METC NIEHS Short-Term Research Training for Minority Students Grant. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Investigating interactions amongst stromal cells, cytokines, and progenitor cells in disruption of hematopoiesis by PAHs. Also studies the effects of bacterial leukotoxins and endotoxin on leukocytes and endothelial cells. Investigating the importance of the AhR in innate immunity to bacterial infection. Advisor to METC Graduate Students: Shawn Heidel (1999) and Paul Stevens (Masters-1995) Mentor to METC Post Docs: Todd Page (2003), Alice Yuroff (2004) and Alhaji N'jai (2007)
DRINKWATER, Norman R, PhD - Professor, School of Medicine and Public Health, Oncology. Affiliated with METC since 1987. Genetics of Chemical Carcinogenesis and Mutagenesis. Molecular mechanisms of carcinogenesis and mutagenesis. Genetic susceptibility to carcinogenesis. Advisor to METC Graduate Students: Mara Feld (2008)
EISENSTEIN, Richard S, PhD - Professor, College of Agricultual and Life Sciences, Nutritional Sciences. Affiliated with METC since 1996. Cellular and Genetic Toxicology. Iron. Regulation of iron metabolism. Molecular regulation of the synthesis of iron transport and storage proteins.
ELFARRA, Adnan A, PhD - Professor of Toxicology, Department of Comparative Biosciences, School of Veterinary Medicine and Division of Pharmaceutical Sciences, School of Pharmacy. Affiliated with METC since 1987. Bioactivation; Cellular and Molecular Basis for Toxicity and Target Organ Selectivity; Biomarkers of Exposure and Effects. TRAINER and PI on Pre- and Post Doctoral Training Grant. Deputy PI and TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Bioactivation; Biomarkers of Exposure and Effects. Cellular and Genetic Toxicology. Toxicant and carcinogen metabolism. Mechanisms of toxicity and target organ selectivity. DNA and hemoglobin modifications. Toxicity of the industrial chemicals trichloroethylene, tetrachloroethylene, 1,3-butadiene, and related compounds. Advisor to METC Graduate Students or Trainees: Nella Barshteyn (current), Roy Irving (current), Rachel Novick (current), Joe Dever (2008), Christopher Sprague (2004), Sjofn Gunnarsdottir (2002), Sharon Ripp (1998), Rebecca Selzer (1997), Jane Sharer (1993), Peter Sausen (1992), In Young Hwang (1992), Renee Krause (1992)
GOULD, Michael N, PhD - Professor, School of Medicine and Public Health. Affiliated with METC since 1979. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Molecular Biology of Breast Cancer. Identification of genes that prevent breast cancer. Signaling pathway differences between H-Ras and K-Ras oncogenes and role in organ-specific carcinogenesis. Molecular basis of selective cell death and proliferation inhibition through study of effects of monoterpene drugs and other potential chemoprotective agents. Breast cancer risk assessment by surrogate biomarkers. Advisor to METC Graduate Students: Tai Yu-Tzu (1996), Sandra Eldridge (1988), Jennifer Ariazi (2003) Mentor to METC post-doc: Michele Cotroneo (2004), Lauri Shepel (1991-1992), Lisa Seidman (1985-1986)
HEIDEMAN, Warren, PhD - Professor, School of Pharmacy. Affiliated with METC since 1997. Cellular and Genetic Toxicology. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Developmental toxicology of TCDD in zebrafish. Regulation of yeast cell cycle by signal transduction pathways. Advisor to METC Graduate Students and Trainees: Narae Lee (current), Vatsal Mehta (current), Kevin Lanham (current), Dagmara Antkiewicz (2007), Bing Liu (1996)
HUTTENLOCHER, Anna, MD - Associate Professor, School of Medicine and Public Health, Pediatrics, Medicine. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Current projects in the laboratory employ many different techniques including (1) cell culture, (2) time lapse videomicroscopy and other assays of cell migration both in cultured cells and within living organisms (3) ectopic expression of genes carrying site-directed mutations, (4) fluorescence microscopy (use of GFP-fusion proteins) and (5) gene discovery by expression cloning and retroviral knock out techniques. Mentor to METC Post-Doc: Peter Cavnar (current)
JARRARD, David F, MD, PhD - Associate Professor, School of Medicine and Public Health, Surgery, Urology. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Prostate Cancer. Oxidative Stress. Insulin-Like Growth Factor II. DNA methylation in cancer development Molecular genetics of prostate cancer. Advisor to METC Graduate Students: Josh Desotelle (current), J. Lea Roberts (MS 2007)
JEFCOATE, Colin R, PhD - Professor, School of Medicine and Public Health, Molecular and Cellular Pharmacology. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre- and Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Roles of cytochrome P4501B1 and Ah Receptor in fat pad development, bone marrow toxicity and carcinogenesis in susceptible mouse strains (intestines, prostate, and mammary gland). Effects of polycyclic aromatic hydrocarbons and PCBs in these processes Molecular mechanism of cholesterol conversion to steroid hormones. Effects of obesity and steroid synthesis and carcinogenesis. Advisor to METC Graduate Students: Melissa Cimafranca(2006), Noe Galvan(2004), Paul Hanlon(2003), David Alexander (1999), Leo Ganem(1999), Paul Brake(1997), Michael Dibartolomeis Jr(1984). Mentor to METC Post-Docs: Sakina Eltom (1996), Shelley Larsen-Su (1999), Craig Marcus (1983-1984), Maro Christou (1984 & 1986)
JOHNSON, Jeffrey A, PhD - Associate Professor, School of Pharmacy. Affiliated with METC since 1999. (METC Alumni 1992) TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Alzheimer's. Amyotrophic Lateral Sclerosis. Huntington's. Parkinson's. Autoimmune Disease. Molecular mechanism of tert-butylhydroquinone (tBHQ) activation of Antioxidant Response Element-driven genes in neuroblastoma cells, primary neuronal and glial cultures, and in vivo. How ARE-driven genes block cell death. Effect of overexpression of amyloid precursor protein on the ARE and antioxidant genes in neurons and glia. Advisor to METC Graduate Students: Marcus Calkins (current), Jong-Min Lee (2003). Mentor to METC Post-Docs: Neal Burton (current), Jon Kern (2004), Julie Kern (2004)
KEELY, Patricia, PhD - Associate Professor,School of Medicine and Public Health, Pharmacology. Affiliated with METC since 2007. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Cancer Biology, Cell Sructure, Extracellular matrices, Cell Migration and Cell Communication. Appropriate cellular interactions with the extracellular matrix (ECM) help to establish normal cellular architecture and differentiation. During oncogenic transformation, these normal interactions with the ECM are profoundly altered, resulting in cells that lose their polarization and differentiation, lose anchorage dependent growth control, and acquire a migratory, invasive phenotype. Our lab is interested in understanding, at a molecular level, how cellular interactions with the ECM determine differentiation and epithelial polarization, and how these interactions are altered during carcinogenesis to result in invasive, metastatic carcinoma. Mentor to METC Post-Doc: Suzanne Ponik (current)
KELLER, Nancy P, PhD - Professor, School of Medicine and Public Health, Microbiology, and College of Agriculture and Life Sciences, Plant Pathology. Affiliated with METC since 2002. Host-Fungal Interactions. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Invasive aspergillosis in immunocompromised patients; molecular genetics of mycotoxin biosynthesis; fungal development; host-fungal interactions leading to toxin production and sporulation. Mentor to METC Post-Docs: Marion Brodhagen (2006), Graeme Garvey (current)
KLEIN, Bruce S., PhD - Professor, Pediatrics, Internal Medicine and Medical Microbiology and Immunology. Affiliated with METC in September 2008. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Molecular medical mycology -- cellular and molecular basis of immunity to medical fungi; genetics of virulence; molecular mechanisms of pathogenesis. Advisor to METC Trainee: Rene Roy (current)
MUKHTAR, Hasan, PhD - Evan P. Helfaer Professor, School of Medicine and Public Health, Dermatology Affiliated with METC since 2006. Apoptosis, Chemical Carcinogenesis, Chemoprevention, Cytochrome P450, Metabolic Basis of Toxicity, Photocarcinogenesis, Tumor Promotion/Prevention. Advisor to METC Graduate Students: Rohinton Tarapore
NIETO, F. Javier, MD, PhD, MPH - Helfaer Professor of Public Health, Department of Population Health Sciences. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Impact of environment on cardiovascular disease. Epidemiology, markers of subclinical atherosclerosis, emerging risk factors for cardiovascular disease (homocysteine, inflammation markers, chronic infections), health consequences of sleep disorders and psychosocial stress. He is also interested in methodological issues in epidemiology and in the teaching of epidemiologic methods.
PEDERSON, Joel, PhD - Associate Professor, College of Agricultural and Life Sciences, Soil Science. Affiliated with METC since 2001. TRAINER on METC NIEHS Pre- and Post Doctoral Training Grant. Fate, transport and bioavailability of organic toxicants and engineered nanoparticles in terrestrial and aquatic environments. Environmental transmission of prion diseases. Advisor to METC Graduate Students:
Paige Wiecinski (current), Sarah Yang (current), (Kennedy) Ned Rubert (2008), Heidi Bialk (2006), and Kristin Phillips (MS-2005)
PETERSON, Richard E, PhD - Professor, School of Pharmacy. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. AhR Signaling. Reproductive and Developmental Toxicology. Mouse and zebrafish, Dioxin (TCDD), Prostate Growth, Develoment and Cancer, Heart Development, Nanotoxicology. Advisor to METC Graduate Students: Sarah Allgeier (2007), Emmie Dengler (MS 2007), Sara Carney (2005), Amy Prasch (2004), Eric Andreasen (2001), Christian Abnet (1998), Michael Hornung (1998), James Kleeman (1998), Beth Roman (1997), Erick Zabel (1995), Jack VandenHeuvel (1991), and Mark Seefeld (1982). Mentor to METC Post-Docs: Wayne Fritz (2003), Carl Potter (1982-1983), Mary Vomachka (1984-1985), Shahanara Saroya (1991-1992), Robert Tanguay (1996-1997), Tisha King Heiden (2006-2008), Susan Bello (2000-2001)
SANDGREN, Eric P, VMD, PhD - Associate Professor, School of Veterinary Medicine, Pathogiological Sciences. Affiliated with METC since xxxx. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Genetic and Extracellular Regulation of Tissue Growth. Molecular mechanisms of carcinogenesis; transgenic mouse models of cancer genetics. Studies of xenogeneic transplantation and human hepatocyte biology in rodents. Advisor to METC Graduate Students: Patricia Boley (current), Ly Pham (current), Teresa Weglarz (2000). Mentor to METC Post-Docs: Teresa Rose-Hellekant (1997-1998)
SHEIBANI, Nader, PhD - Associate Professor, School of Medicine and Public Health, Ophthalmology & Visual Science. Affiliated with METC since 2001. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. and Short-Term Research Minority Training Grant. Vascular Biology. Regulation of angiogenesis, cellular adhesive mechanisms, focal adhesion and integrin signal transduction, pathological neovascularization and eye diseases.
SMITH, Susan M, PhD - Professor, College of Agricultural and Life Sciences, Nutritional Science. Affiliated with METC since 1996. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Human Development and Risk. Risk and mechaism underlying trichloroethylene-induced cardiac defects. Fetal Alcohol Syndrome. Retinoids. Trichloroethylene. Molecular mechanism underlying alcohol-related birth defects (ethanol-dependent signal transduction and Ca2+ transients in triggering neuronal apoptosis). Retinoid action in fetus and adult, with emphasis on vitamin A status and heart function. Advisor to METC Graduate Students: Matt Brody (current), Echoleah Rufer (current), Fernandez Cavieres (2001),Katherine Kragtorp (2003), Evan Thackaberry (2002),
TIBBETTS, Randal S, PhD - Associate Professor, School of Medicine and Public Health, Dermatology - TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Attempting to understand how mammalian cells respond to genetic damage, with emphasis on the ATM/ATR family of tumor suppressor genes. His laboratory is also exploring the process of neurodegeneration in ataxia-telangiectasia (A-T), an inherited genetic disease that results from mutations in ATM. By identifying defective pathways in A-T, his group hopes to learn more about other neurodegenerative conditions such as Parkinson's disease and Alzheimer's, which may share common roots with A-T. Advisor to METC Gradaute Student: John Hutchinson
TREPANIER, Lauren A, DVM, PhD - Associate Professor, School of Veterinary Medicine, Medical Sciences. Affiliated with METC since 1997. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. TRAINER on the METC NIEHS Short-Term Research Training for Minority Students Grant. Drug Hypersensitivity. HIV. Drug Detoxification. Cytochrome b5 Reductase. Genetic and biochemical variability in drug metabolism and its relationship to adverse drug reactions and drug toxicity. Arylamines, nitroso compound and hydroxylamines. Sulfonamide drug hypersensitivity in AIDS patients. Therapeutic drug monitoring for veterinary patients. Advisor to METC Graduate Students: Keelia Rhodes (current) and Joe Kurian (2006)
VERMA, Ajit K, PhD - Professor, School of Medicine and Public Health, Human Oncology. Affiliated with METC since 1985. TRAINER on METC NIEHS Pre-Post Doctoral Training Grant. Research goals: Defining mechanisms of skin and prostate cancer using transgenic and gene knock-out models. Protein kinase C signaling in cancer induction. Caner chemoprevention. Advisor to METC Graduate Students: Jordan Sand (current)
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