Study Examines Genetics, Incidence of Age-Related Macular Degeneration
Madison, Wisconsin - A new report from the Beaver Dam Eye Study helps show how much variant genes contribute to the risk of developing age-related macular degeneration (
Dr. Ronald Klein, of the University of Wisconsin School of Medicine and Public Health, and colleagues describe the relationship of age and risk alleles (variant gene forms) with the incidence and progression of age-related macular degeneration (
Klein, professor of ophthalmology and visual sciences, looked at the relationships of variant genes in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with the incidence and progression of age-related macular degeneration during a 20-year period in the Beaver Dam Eye Study.
In the study, 4,282 individuals between the ages of 43 and 86 years at a baseline examination in 1988-1990 were enrolled and participated in at least one examination spaced five years apart during the 20-year period. Of this group, 66 percent were classified as low-risk; 26 percent medium-risk and eight percent high genetic risk for
The study results indicate that almost half – 46.5 percent – of those in the high genetic-risk group went on to develop early age-related macular degeneration even though they did not have
“These population-based data provide estimates of the long-term risk of the incidence and progression of
The article was published Online First by Archives of Ophthalmology, a JAMA Network publication.
Date Published: 11/09/2012