Undergraduate education

Colgate University, BA, 2009

Years in MSTP



Cellular and molecular pathology, 2015


David O'Connor, PhD

Thesis title

Exploring the Primate Plasma Virome: Implications for Humans Health and Disease


Pathology – Anatomic and Clinical, Washington University, School of Medicine, 2017-

Current position

Resident, Department of Pathology, Washington University, School of Medicine

Undergraduate and/or masters publications

Moralejo D, Yanay O, Kernan K, Bailey A, Lernmark A, Osborne W. Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats. J Biosci Bioeng. 2011 Apr;111(4):383-7. PMID: 21216666; PMCID: PMC3074004.

Hensley SE, Das SR, Gibbs JS, Bailey AL, Schmidt LM, Bennink JR, Yewdell JW. Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance. PLoS One. 2011 Feb 22;6(2):e15190. PMID: 21364978; PMCID: PMC3043005.

Grebe KM, Takeda K, Hickman HD, Bailey AL, Embry AC, Bennink JR, Yewdell JW. Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis. J Immunol. 2010 Jan 15;184(2):540-4. PMID: 20018617; PMCID: PMC2941093.

Hensley SE, Das SR, Bailey AL, Schmidt LM, Hickman HD, Jayaraman A, Viswanathan K, Raman R, Sasisekharan R, Bennink JR, Yewdell JW. Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science. 2009 Oct 30;326(5953):734-6. PMID: 19900932; PMCID: PMC2784927.

PhD publications

Cornish JP, Moore IN, Perry DL, Lara A, Minai M, Promeneur D, Hagen KR, Virtaneva K, Paneru M, Buechler CR, O'Connor DH, Bailey AL, Cooper K, Mazur S, Bernbaum JG, Pettitt J, Jahrling PB, Kuhn JH, Johnson RF. Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis. Viruses. 2019 Jan 15;11(1). pii: E67. PMID: 30650570; PMCID: PMC6356329.

Heffron AS, Mohr EL, Baker D, Haj AK, Buechler CR, Bailey A, Dudley DM, Newman CM, Mohns MS, Koenig M, Breitbach ME, Rasheed M, Stewart LM, Eickhoff J, Pinapati RS, Beckman E, Li H, Patel J, Tan JC, O'Connor DH. Antibody responses to Zika virus proteins in pregnant and non-pregnant macaques. PLoS Negl Trop Dis. 2018 Nov 27;12(11):e0006903. PMID: 30481182; PMCID: PMC6286021.

Buechler C, Semler M, Baker DA, Newman C, Cornish JP, Chavez D, Guerra B, Lanford R, Brasky K, Kuhn JH, Johnson RF, O'Connor DH, Bailey AL. Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus. Viruses. 2018 Dec 10;10(12). pii: E701. PMID: 30544677; PMCID: PMC6316555.

Buechler CR, Bailey AL, Lauck M, Heffron A, Johnson JC, Campos Lawson C, Rogers J, Kuhn JH, O'Connor DH. Genome Sequence of a Novel Kunsagivirus (Picornaviridae: Kunsagivirus) from a Wild Baboon (Papio cynocephalus). Genome Announc. 2017 May 4;5(18). pii: e00261-17. PMID: 28473378; PMCID: PMC5477186.

Buechler CR, Bailey AL, Weiler AM, Barry GL, Breitbach ME, Stewart LM, Jasinska AJ, Freimer NB, Apetrei C, Phillips-Conroy JE, Jolly CJ, Rogers J, Friedrich TC, O'Connor DH. Seroprevalence of Zika Virus in Wild African Green Monkeys and Baboons. mSphere. 2017 Mar 8;2(2). pii: e00392-16. eCollection 2017 Mar-Apr. PMID: 28289727; PMCID: PMC5343173.

Moncla LH, Weiler AM, Barry G, Weinfurter JT, Dinis JM, Charlier O, Lauck M, Bailey AL, Wahl-Jensen V, Nelson CW, Johnson JC, Caì Y, Goldberg TL, O'Connor DH, Jahrling PB, Kuhn JH, Friedrich TC. Within-host evolution of simian arteriviruses in crab-eating macaques. J Virol. 2017 Jan 31;91(4). PMID: PMC5286893.

Yú SQ, Caì Y, Lyons C, Johnson RF, Postnikova E, Mazur S, Johnson JC, Radoshitzky SR, Bailey AL, Lauck M, Goldberg TL, O'Connor DH, Jahrling PB, Friedrich TC, Kuhn JH. Specific Detection of Two Divergent Simian Arteriviruses Using RNAscope In Situ Hybridization. PLoS One. 2016 Mar 10;11(3):e0151313. eCollection 2016. PMID: 26963736; PMCID: PMC4786270.

Bailey AL, Lauck M, Ghai RR, Nelson CW, Heimbruch K, Hughes AL, Goldberg TL, Kuhn JH, Jasinska AJ, Freimer NB, Apetrei C, O'Connor DH; for “The International Vervet Research Consortium”. Arteriviruses, pegiviruses, and lentiviruses are common among wild African monkeys. J Virol. 2016 Aug 1;90(15):6724-37. PMID: 27170760; PMCID: PMC4944300.

Kuhn JH, Lauck M, Bailey AL, Shchetinin AM, Vishnevskaya TV, Bào Y, Ng TF, LeBreton M, Schneider BS, Gillis A, Tamoufe U, Diffo JL, Takuo JM, Kondov NO, Coffey LL, Wolfe ND, Delwart E, Clawson AN, Postnikova E, Bollinger L, Lackemeyer MG, Radoshitzky SR, Palacios G, Wada J, Shevtsova ZV, Jahrling PB, Lapin BA, Deriabin PG, Dunowska M, Alkhovsky SV, Rogers J, Friedrich TC, O'Connor DH, Goldberg TL. Reorganization and expansion of the nidoviral family Arteriviridae. Arch Virol. 2016 Mar;161(3):755-68. PMID: 26608064; PMCID: PMC5573231.

Wahl-Jensen V, Johnson JC, Lauck M, Weinfurter JT, Moncla LH, Weiler AM, Charlier O, Rojas O, Byrum R, Ragland DR, Huzella L, Zommer E, Cohen M, Bernbaum JG, Caì Y, Sanford HB, Mazur S, Johnson RF, Qin J, Palacios GF, Bailey AL, Jahrling PB, Goldberg TL, O'Connor DH, Friedrich TC, Kuhn JH. Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques. MBio. 2016 Feb 23;7(1). PMID: 26908578; PMCID: PMC4791849.

Bailey AL, Lauck M, Sibley SD, Friedrich TC, Kuhn JH, Freimer NB, Jasinska AJ, Phillips-Conroy JE, Jolly CJ, Marx PA, Apetrei C, Rogers J, Goldberg TL, O'Connor DH. Zoonotic Potential of Simian Arteriviruses. J Virol. 2015 Nov 11;90(2):630-5. PMID: 26559828; PMCID: PMC4702702.

Dudley DM, Bailey AL, Mehta SH, Hughes AL, Kirk GD, Westergaard RP, O'Connor DH. Cross-clade simultaneous HIV drug resistance genotyping for reverse transcriptase, protease, and integrase inhibitor mutations by Illumina MiSeq.
Retrovirology. 2014 Dec 23;11(1):122. PMID: 25533166; PMCID: PMC4302432.

Lauck M, Alkhovsky SV, Bào Y, Bailey AL, Shevtsova ZV, Shchetinin AM, Vishnevskaya TV, Lackemeyer MG, Postnikova E, Mazur S, Wada J, Radoshitzky SR, Friedrich TC, Lapin BA, Deriabin PG, Jahrling PB, Goldberg TL, O'Connor DH, Kuhn JH. Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses. J Virol. 2015 Aug 1;89(15):8082-7. PMID: 25972539; PMCID: PMC4505640.

Ghai RR, Sibley SD, Lauck M, Dinis JM, Bailey AL, Chapman CA, Omeja P, Friedrich TC, O'Connor DH, Goldberg TL. Deep sequencing identifies two genotypes and high viral genetic diversity of human pegivirus (GB virus C) in rural Ugandan patients. J Gen Virol. 2013 Dec;94 Pt 12:2670-8. PMID: 24077364; PMCID: PMC3836497.

Bailey AL, Lauck M, Weiler A, Sibley SD, Dinis JM, Bergman Z, Nelson CW, Correll M, Gleicher M, Hyeroba D, Tumukunde A, Weny G, Chapman C, Kuhn JH, Hughes AL, Friedrich TC, Goldberg TL, O'Connor DH. High genetic diversity and adaptive potential of two simian hemorrhagic Fever viruses in a wild primate population. PLoS One. 2014 Mar 20;9(3):e90714. PMID: 24651479; PMCID: PMC3961216.

Sibley SD, Lauck M, Bailey AL, Hyeroba D, Tumukunde A, Weny G, Chapman CA, O'Connor DH, Goldberg TL, Friedrich TC. Discovery and characterization of distinct simian pegiviruses in three wild african old world monkey species. PLoS One. 2014 Jun 11;9(2):e98569. eCollection 2014. PMID: 24918769; PMCID: PMC4053331.

Lauck M, Bailey AL, Andersen KG, Goldberg TL, Sabeti PC, O'Connor DH. GB virus C co-infections in West African Ebola patients. J Virol. 2015 Feb;89(4):2425-9. PMID: 25473056; PMCID: 4338908.

Ericsen AJ, Starrett GJ, Greene JM, Lauck M, Raveendran M, Deiros DR, Mohns MS, Vince N, Cain BT, Pham NH, Weinfurter JT, Bailey AL, Budde ML, Wiseman RW, Gibbs R, Muzny D, Friedrich TC, Rogers J, O'Connor DH. Whole genome sequencing of SIV-infected macaques identifies candidate loci that may contribute to host control of virus replication. Genome Biology. 2014 Nov 7;15(11):478. PMID: 25418588; PMCID: 4223156.

Bailey AL, Lauck M, Sibley SD, Pecotte J, Rice K, Weny G, Tumukunde A, Hyeroba D, Greene J, Correll M, Gleicher M, Friedrich TC, Jahrling PB, Kuhn JH, Goldberg TL, Rogers J, O'Connor DH. Two Novel Simian Arteriviruses in Captive and Wild Baboons (Papio spp.). J Virol. 2014 Nov 15;88(22):1323-9. PMID: 25187550; PMCID: PMC4249091.

Caì Y, Postnikova EN, Bernbaum JG, Yú SQ, Mazur S, Deiuliis NM, Radoshitzky SR, Lackemeyer MG, McCluskey A, Robinson PJ, Haucke V, Wahl-Jensen V, Bailey AL, Lauck M, Friedrich TC, O'Connor DH, Goldberg TL, Jahrling PB, Kuhn JH. Simian Hemorrhagic Fever Virus Cell Entry is Dependent on CD163 and Uses a Clathrin-mediated Endocytosis-like Pathway. J Virol. 2015 Jan1;89(1):844-56. PMID: 25355889; PMCID: PMC4301170.

Lauck M, Palacios G, Wiley MR, L Y, Fang Y, Lackemeyer MG, Caì Y, Bailey AL, Postnikova E, Radoshitzky SR, Johnson RF, Alkhovsky SV, Deriabin PG, Friedrich TC, Goldberg TL, Jahrling PB, O'Connor DH, Kuhn JH. Genome Sequences of Simian Hemorrhagic Fever Virus Variant NIH LVR42-0/M6941 Isolates (Arteriviridae: Arterivirus). Genome Announc. 2014 Oct 9;2(5). PMID: 25301647; PMCID: PMC4192379.

Correll M, Bailey AL, Sarikaya A, O'Connor DH, Gleicher M. LayerCake: a tool for the visual comparison of viral deep sequencing data. Bioinformatics. 2015 Nov 1;31(21):3522-8. PMID: 26153515; PMCID: PMC4626748.

Yanay O, Bailey AL, Kernan K, Zimmerman JJ, Osborne WR. Effects of exendin-4, a glucagon like peptide-1 receptor agonist, on neutrophil count and inflammatory cytokines in a rat model of endotoxemia. J Inflamm Res. 2015 Jul 24;8:129-35. PMID: 26244029; PMCID: PMC4521677.

Bailey AL, Lauck M, Mohns M, Peterson EJ, Beheler K, Brunner KG, Crosno K, Mejia A, Mutschler J, Gehrke M, Greene J, Ericsen AJ, Weiler A, Lehrer-Brey G, Friedrich TC, Sibley SD, Kallas EG, Capuano S 3rd, Rogers J, Goldberg TL, Simmons HA, O'Connor DH. Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection. Sci Transl Med. 2015 Sep 16;7(305):305ra144. PMID: 26378244; PMCID: PMC4605385.

Bailey AL, Buechler CR, Matson DR, Peterson EJ, Brunner KG, Mohns MS, Breitbach M, Stewart LM, Ericsen AJ, Newman CM, Koenig MR, Mohr E, Tan J, Capuano S 3rd, Simmons HA, Yang DT, O'Connor DH. Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. PLoS Pathog. 2017 Oct 26;13(10):e1006692. PMID: 29073258; PMCID: PMC5675458.