Undergraduate education

Allegheny College, BS, 2003

Years in MSTP

2004-2013

PhD

Molecular and cellular pharmacology, 2011

Mentor

Timothy Kamp, MD, PhD

Thesis title

Regulation of sarcolemmal turnover of cardiac CAv1.2 L-type CA2+ channels by the small GTPase Rab11b

Residency

Psychiatry, University of California-San Diego, 2013-

Current position

Resident, Department of Psychiatry, University of California-San Diego, School of Medicine

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PhD publications

Best JM, Kamp TJ. Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes. J Mol Cell Cardiol. 2012 Feb;52(2):376-87. PMID: 21888911; PMCID: PMC3264751.

Best JM, Foell JD, Buss CR, Delisle BP, Balijepalli RC, January CT, Kamp TJ. Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. Am J Physiol Cell Physiol. 2011 May;300(5):C1023-33. PMID: 21248079; PMCID: PMC3093944.

Best JM, Kamp TJ. A sympathetic model of L-type Ca2+ channel-triggered arrhythmias. Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H3-4. PMID: 19897704; PMCID: PMC2806129.

Delisle BP, Underkofler HA, Moungey BM, Slind JK, Kilby JA, Best JM, Foell JD, Balijepalli RC, Kamp TJ, January CT. Small GTPase determinants for the Golgi processing and plasmalemmal expression of human ether-a-go-go related (hERG) K+ channels. J Biol Chem. 2009 Jan 30;284(5):2844-53. PMID: 19029296; PMCID: PMC2631954.

Markandeya YS, Feng L, Best JM, Lea ML, Buss CR, Kamp TJ, Balijepalli RC. Loss of Caveolin-3 Results in Qt(C) Prolongation and Causes Delayed Cardiac Repolarization in a Cardiac-Specific Conditional CAV-3 Knockout Mouse Model. Biophysical Journal. 2013 Jan 29;104(2):209A-209A.

Boczek NJ, Best JM, Tester DJ, Giudicessi JR, Middha S, Evans JM, Kamp TJ, Ackerman MJ. Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome. Circ Cardiovasc Genet. 2013 Jun;6(3):279-89. PMID: 23677916; PMCID: PMC3760222.