University of Chicago, BA, 1990
Years in MSTP
Human oncology, 1997
Paul Sondel, MD, PhD
Functional Responses and Receptor Usage of Human Lymphocytes in Response to Interlukin-2 and Interlukin-15
Pediatrics, Children's Hospital of Boston
Hematology-oncology, Children's Hospital of Boston
Assistant professor, Department of Pediatrics, Biological Sciences Division, School of Medicine, University of Chicago
Monson NL, Fenske TJ, Wei S, Okragly AJ, de Jong JL, Haak-Frendscho M, O'Shea J, Djeu J, Sondel PM. A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1beta2. J Leukoc Biol. 2001 Mar;69(3):419-25. PMID: 11261789.
De Jong JL, Farner NL, Sondel PM. Distinctions in lymphocyte responses to IL-2 and IL-15 reflect differential ligand binding interactions with the IL-2Rbeta chain and suggest differential roles for the IL-2Ralpha and IL-15Ralpha subunits. Cytokine. 1998 Dec;10(12):920-30. PMID: 10049515.
De Jong JL, Farner NL, Javorsky BR, Lindstrom MJ, Hank JA, Sondel PM. Differential quantitative effects of interleukin (IL)-2 and IL-15 on cytotoxic activity and proliferation by lymphocytes from patients receiving in vivo IL-2 therapy. Clin Cancer Res. 1998 May;4(5):1287-96. PMID: 9607589.
Farner NL, Gan J, de Jong JL, Leary TP, Fenske TS, Buckley P, Dunlap S, Sondel PM. Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15. Cytokine. 1997 May;9(5):316-27. PMID: 9195130.
De Jong JL, Farner NL, Widmer MB, Giri JG, Sondel PM. Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex. J Immunol. 1996 Feb 15;156(4):1339-48. PMID: 8568232.
Kaur I, de Jong J, Schell K, Hank J, Fisch P, Sondel PM. Human peripheral gamma delta T cells are stimulated by Daudi Burkitt's lymphoma and not by any other Burkitt's lymphoma tested. Cell Immunol. 1994 Jun;156(1):54-61. PMID: 8200042.