Undergraduate education

University of Michigan, BS, 1994

Years in MSTP

1995-2005

PhD

Molecular and cellular pharmacology, 2003

Mentor

Johannes Hell, PhD

Thesis title

The Association of Post-Synaptic Density Protein 95 with the N-Methyl-D-Aspartate Type Glutamate Receptor: Specificity of PDZ Domain Interactions and Physiological Consequences of Binding

Residency

Rehabilitation medicine, University of Michigan, 2006-2009

Current position

Physiatrist, Sister Kenny Rehabilitation Institute

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PhD publications

Lu Y, Zhang M, Lim IA, Hall DD, Allen M, Medvedeva Y, McKnight GS, Usachev YM, Hell JW. AKAP150-anchored PKA activity is important for LTD during its induction phase. J Physiol. 2008 Sep 1;586(Pt 17):4155-64. PMID: 18617570; PMCID: PMC2652176.

Lim IA, Merrill MA, Chen Y, Hell JW. Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect. Neuropharmacology. 2003 Nov;45(6):738-54. PMID: 14529713.

Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW. Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102. J Biol Chem. 2003 Apr 25;278(17):15040-8. PMID: 12576483.

Leonard AS, Bayer KU, Merrill MA, Lim IA, Shea MA, Schulman H, Hell JW. Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin. J Biol Chem. 2002 Dec 13;277(50):48441-8. PMID: 12379661.

Lim IA, Hall DD, Hell JW. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem. 2002 Jun14;277(24):21697-711. PMID: 11937501.

Leonard AS, Lim IA, Hemsworth DE, Horne MC, Hell JW. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3239-44. PMID: 10077668; PMCID: PMC15926.