Undergraduate education

Ripon College, BA, 1992

Years in MSTP

1992-2000

PhD

Biochemistry, 1998

Mentor

William Reznikoff, PhD

Thesis title

Structure/Function Studies of the TN5 transposase: Models for Inhibition and Catalysis

Residency

Medicine, Washington University, 2000-2003

Fellowship

Infectious disease, Washington University, 2003-2006

Current position

Executive medical director, global head of clinical pharmacology, EMD Serono, Inc.

Undergraduate/masters publications

Twining SS, Kirschner SE, Mahnke LA, Frank DW. Effect of Pseudomonas aeruginosa elastase, alkaline protease, and exotoxin A on corneal proteinases and proteins. Invest Ophthalmol Vis Sci. 1993 Aug;34(9):2699-712. PMID: 8344792.

PhD publications

Reznikoff WS, Bhasin A, Davies DR, Goryshin IY, Mahnke LA, Naumann T, Rayment I, Steiniger-White M, Twining SS. Tn5: A molecular window on transposition. Biochem Biophys Res Commun. 1999 Dec 29;266(3):729-34. PMID: 10603311.

Davies DR, Mahnke Braam L, Reznikoff WS, Rayment I. The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution. J Biol Chem. 1999 Apr 23;274(17):11904-13. PMID: 10207011.

Mahnke Braam LA, Goryshin IY, Reznikoff WS. A mechanism for Tn5 inhibition. carboxyl-terminal dimerization. J Biol Chem. 1999 Jan 1;274(1):86-92. PMID: 9867814.

Mahnke Braam LA, Reznikoff WS. Functional characterization of the Tn5 transposase by limited proteolysis. J Biol Chem. 1998 May 1;273(18):10908-13. PMID: 9556567.

Weinreich MD, Mahnke-Braam L, Reznikoff WS. A functional analysis of the Tn5 transposase. Identification of domains required for DNA binding and multimerization. J Mol Biol. 1994 Aug 12;241(2):166-77. PMID: 8057357.