Undergraduate education

University of Wisconsin-Madison, BS, 2002

Years in MSTP

2005-2014

PhD

Cellular and molecular biology, 2012

Mentor

Loren Denlinger, MD, PhD

Thesis title

The Effects of Functional P2X7 on Asthma and Rhinovirus Infection

Residency

Pathology, University of Michigan, Medical School, 2014-

Current position

Resident, Department of Pathology, University of Michigan, Medical School

View profile

PhD publications

Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF Jr; the NHLBI Asthma Clinical Research Network Investigators. P2X 7 –Regulated Protection from Exacerbations and Loss of Control is Independent of Asthma Maintenance Therapy. Am J Respir Crit Care Med. 2013 Jan 1;187(1):28-33. PMID: 23144325; PMCID: PMC3570642.

Shi L, Manthei DM, Guadarrama AG, Lenertz LY, Denlinger LC. Rhinovirus-Induced IL-1β Release from Bronchial Epithelial Cells Is Independent of Functional P2X7. Am J Respir Cell Mol Biol. 2012 Sep;47(3):363-71. PMID: 22493010; PMCID: PMC3488691

Manthei DM, Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Gern JE, Lemanske RF Jr, Denlinger LC. Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function. J Allergy Clin Immunol. 2012 Aug;130(2):496-502. PMID: 22743305; PMCID: PMC3551624.

Schwantes EA, Manthei DM, Denlinger LC, Evans MD, Gern JE, Jarjour NN, Mathur SK.Interferon Gene Expression in Sputum Cells Correlates with the Asthma Index Score During Virus-Induced Exacerbations. Clin Exp Allergy. 2014 Jun;44(6):813-21. PMID: 24450586; PMCID: PMC4037351.

Manthei DM, Schwantes EA, Mathur SK, Guadarrama AG, Kelly EA, Gern JE, Jarjour NN, Denlinger LC. Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations. Clin Exp Allergy. 2014 Dec;44(12):1484-93. PMID: 25109477; PMCID: PMC4247169.

Olson AA, Evans MD, Johansson MW, Kim CH, Manthei DM, Gaumnitz EA, Mathur SK. Role of food and aeroallergen sensitization in eosinophilic esophagitis in adults. Ann Allergy Asthma Immunol. 2016 Oct;117(4):387-393.e2. PMID: 27590636; PMCID: PMC5065768.