Undergraduate education

University of Wisconsin-Madison, BA, 2005

Years in MSTP



Molecular and cellular pharmacology, 2012


Shigeki Miyamoto, PhD

Thesis title

Establishing the Molecular Function of the Zinc Finger Domain of NEMO in DNA Damage-Dependent NF-κB Activation


Obstetrics and Gynecology, University of Wisconsin-Madison, School of Medicine and Public Health, 2014-2018


Gynecologic Oncology, University of Michigan, 2018-

Current position

Fellow, Department of Obstetrics & Gynecology - Gynecologic Oncology, University of Michigan Medical School

PhD publications

Hwang B, McCool K, Wan J, Wuerzberger-Davis SM, Young EW, Choi EY, Cingolani G, Weaver BA, Miyamoto S. IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation. J Biol Chem. 2015 Jul 17;290(29):17967-84. PMID: 26060253; PMCID: PMC4505044.

Hwang B, Phan FP, McCool K, Choi EY, You J, Johnson A, Audhya A, Miyamoto S. Quantification of cellular NEMO content and its impact on NF-κB activation by genotoxic stress. PLoS One. 2015 Mar 5;10(3):e0116374. PMID: 25742655; PMCID: PMC4350935.

McCool KW, Miyamoto S. DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out. Immunol Rev. 2012 Mar;246(1):311-26. PMID: 22435563; PMCID: PMC3311051.

McCool K, Miyamoto S. A PAR-SUMOnious mechanism of NEMO activation. Mol Cell. 2009 Nov 13;36(3):349-50. PMID: 19917242.

Jackson SS, Oberley C, Hooper CP, Grindle K, Wuerzberger-Davis S, Wolff J, McCool K, Rui L, Miyamoto S. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling. Exp Cell Res. 2015 Feb 1;33(1):58-72. PMID: 25304104; PMCID: PMC4302062.