Undergraduate education

University of Oklahoma-Norman, BS, 2006

Years in MSTP

2006-2013

PhD

Cellular and molecular biology, 2011

Mentor

David Watkins, PhD

Thesis title

The role of CD8+ T cell responses and viral escape in immune control of simian immunodeficiency virus infection

Residency

Emergency medicine, University of Cincinnati, 2013-2017

Current position

Clinical instructor, Department of Emergency Medicine, Washington University, School of Medicine

Undergraduate and/or masters publications

Teague BN, Pan Y, Mudd PA, Nakken B, Zhang Q, Szodoray P, Kim-Howard X, Wilson PC, Farris AD. Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus. J Immunol. 2007 Jun 15;178(12):7511-5. PMID: 17548583.

Mudd PA, Teague BN, Farris AD. Regulatory T cells and systemic lupus erythematosus. Scand J Immunol. 2006 Sep;64(3):211-8. PMID: 16918689.

Ross J, He YG, Niederkorn JY. Class I disparate corneal grafts enjoy afferent but not efferent blockade of the immune response. Curr Eye Res. 1991 Sep;10(9):889-92. PMID: 1790719.

PhD publications

Mudd PA, Martins MA, Ericsen AJ, Tully DC, Power KA, Bean AT, Piaskowski SM, Duan L, Seese A, Gladden AD, Weisgrau KL, Furlott JR, Kim YI, Veloso de Santana MG, Rakasz E, Iii SC, Wilson NA, Bonaldo MC, Galler R, Allison DB, Piatak Jr M, Haase AT, Lifson JD, Allen TM, Watkins DI. Vaccine-induced CD8(+) T cells control AIDS virus replication. Nature. 2012 Nov 1;491(7422):129-33. PMID: 23023123; PMCID: PMC3883109.

Mudd PA, Ericsen AJ, Burwitz BJ, Wilson NA, O'Connor DH, Hughes AL, Watkins DI. Escape from CD8(+) T cell responses in Mamu-B*00801(+) macaques differentiates progressors from elite controllers. J Immunol. 2012 Apr 1;188(7):3364-70. PMID: 22387557; PMCID: PMC3883983.

Mudd PA, Ericsen AJ, Walsh AD, León EJ, Wilson NA, Maness NJ, Friedrich TC, Watkins DI. CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission. J Virol. 2011 Dec;85(23):12804-10. PMID: 21957309; PMCID: PMC3209381.

Mudd PA, Ericsen AJ, Price AA, Wilson NA, Reimann KA, Watkins DI. Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers. J Virol. 2011 Jul;85(14):7454-9. PMID: 21593153; PMCID: PMC3126606.

Mudd PA, Watkins DI. Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses. Curr Opin HIV AIDS. 2011 May;6(3):197-201. PMID: 21502922; PMCID: PMC3789597.

Neves PC, Rudersdorf RA, Galler R, Bonaldo MC, de Santana MG, Mudd PA, Martins MA, Rakasz EG, Wilson NA, Watkins DI. CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. Vaccine. 2010 Nov 29;28(51):8183-8. PMID: 20939995; PMCID: PMC3179417.

Mudd PA, Piaskowski SM, Neves PC, Rudersdorf R, Kolar HL, Eernisse CM, Weisgrau KL, de Santana MG, Wilson NA, Bonaldo MC, Galler R, Rakasz EG, Watkins DI. The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques—implications for recombinant vaccine design. Immunogenetics. 2010 Sep;62(9):593-600. PMID: 20607226; PMCID: PMC3136048.

Bonaldo MC, Martins MA, Rudersdorf R, Mudd PA, Sacha JB, Piaskowski SM, Costa Neves PC, Veloso de Santana MG, Vojnov L, Capuano S 3rd, Rakasz EG, Wilson NA, Fulkerson J, Sadoff JC, Watkins DI, Galler R. Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques. J Virol. 2010 Apr;84(7):3699-706. PMID: 20089645; PMCID: PMC2838090.

Walsh AD, Bimber BN, Das A, Piaskowski SM, Rakasz EG, Bean AT, Mudd PA, Ericsen AJ, Wilson NA, Hughes AL, O'Connor DH, Maness NJ. Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection. PLoS One. 2013 May 6;8(5):e61383. PMID: 23671565; PMCID: PMC3645990.