Undergraduate education

Massachusetts Institute of Technology, BS, 2010

Years in MSTP

2010-2017

PhD

Cellular and molecular biology, 2015

Mentor

John Kuo, MD

Thesis title

Predictive Biomarkers in the Investigation Into Glioblastoma Heterogeneity: Collagen and hERG

Residency

Radiation oncology, University of Chicago, Medical Center, 2018-

Current position

Transitional year, Henry Ford Health Sciences Center, Detroit

Undergraduate and/or masters publications

Libert S, Bonkowski MS, Pointer K, Pletcher SD, Guarente L. Deviation of innate circadian period from 24h reduces longevity in mice. Aging Cell. 2012 Jun 15. PMID: 22702406.

Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, Guarente L. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell. 2011 Dec 23;147(7):1459-72. PMID: 22169038.

PhD publications

Zhang RR, Pointer KB, Kuo JS. Excitotoxic SLC7A11 Expression Is a Marker of Poor Glioblastoma Survival and a Potential Therapeutic Target. Neurosurgery. 2015 Dec;77(6):N16-7. PMID: 26584321.

Pointer K, Kuo JS, Dempsey RJ. CLARITY-A Clearer View of the Brain. Neurosurgery. 2013 Aug;73(2):N16. PMID: 23867270.

Pointer KB, Clark PA, Zorniak M, Alrfaei BM, Kuo JS. Glioblastoma Cancer Stem Cells: Biomarker and Therapeutic Advances. Neurochem Int. 2014 May;71C:1-7. PMID: 24657832; PMCID: PMC4119816.

Pointer KB, Zhang RR, Kuo JS, Dempsey RJ. Detecting brain tumor with Raman scattering microscopy. Neurosurgery. 2014 Feb;74(2):N12-4. PMID: 24435144.

Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Mol Cancer. 2014 Feb 20;13:31. PMID: 24555568; PMCID: PMC3936893.

Cong D, Zhu W, Shi Y, Pointer KB, Clark PA, Shen H, Kuo JS, Hu S, Sun D. Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival. Carcinogenesis. 2014 Sep;35(9):2014-24. PMID: 24717311; PMCID: PMC4146414.

Lyon W, Mehta TI, Pointer KB, Walden D, Elmayan A, Swanson KI, Kuo JS. Clinton Woolsey: functional brain mapping pioneer. J Neurosurg. 2014 Oct;121(4):983-8. PMID: 25105696; PMCID: PMC4354805.

Zhang RR, Pointer KB, Kuo JS, Dempsey RJ. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Neurosurgery. 2014 Dec;75(6):N9-N10. PMID: 25406627; PMCID: PMC4354805.

Pointer KB, Zhang RR, Kuo JS. Oncolytic Herpes Simplex Virus Glioblastoma Therapy is Potentiated by Tumor Necrosis Factor-α Inhibition. Neurosurgery. 2015 Aug;77(2):N18-20. PMID: 26181790.

Zhang RR, Pointer KB, Kuo JS. New Molecular Insights and Potential Therapies for Diffuse Intrinsic Pontine Glioma. Neurosurgery. 2015 Oct;77(4):N13-4. PMID: 26379176.

Pointer KB, Clark PA, Schroeder AB, Salamat MS, Eliceiri KW, Kuo JS. Association of collagen architecture with glioblastoma patient survival. J Neurosurg. 2017 Jun;126(6):1812-1821. PMID: 27588592; PMCID: PMC5386834.

Pointer KB, Clark PA, Eliceiri KW, Salamat MS, Robertson GA, Kuo JS. Non-torsadogenic human Ether-à-go-go Related Gene (hERG) inhibitors are associated with better survival for high hERG-expressing glioblastoma patients. Clin Cancer Res. 2017 Jan1;23(1):73-80. PMID: 27635088; PMCID: PMC5627655.

Pointer KB, Ko HC, Brower JV, Witek ME, Kimple RJ, Lloyd RV, Harari PM, Baschnagel AM. Small cell carcinoma of the head and neck: An analysis of the National Cancer Database. Oral Oncol. 2017 Jun;69:92-98. PMID: 28559027; PMCID: PMC5553627.