Undergraduate education

Harvard University, BA, 2002

Years in MSTP



Cellular and molecular biology, 2012


Bruce Klein, MD

Thesis title

The active barrier: A role for epithelial cells in chitin induced allergic inflammation


Pediatrics, University of Colorado-Denver, School of Medicine, 2014-2017


Pediatric Critical Care Medicine, St. Louis Children’s Hospital, 2017-

Current position

Fellow, Department of Pediatric Critical Care Medicine, St. Louis Children’s Hospital

Undergraduate and/or masters publications

Levy O, Coughlin M, Cronstein BN, Roy RM, Desai A, Wessels MR. The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol. 2006 Aug 1;177(3):1956-66. PMID: 16849509; PMCID: PMC2881468.

Orange JS, Levy O, Brodeur SR, Krzewski K, Roy RM, Niemela JE, Fleisher TA, Bonilla FA, Geha RS. Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. J Allergy Clin Immunol. 2004 Sep;114(3):650-6. PMID: 15356572.

Levy O, Zarember KA, Roy RM, Cywes C, Godowski PJ, Wessels MR. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol. 2004 Oct 1;173(7):4627-34. PMID: 15383597.

PhD publications

Roy RM, Wüthrich M, Klein BS. Chitin Elicits CCL2 from Airway Epithelial Cells and Induces CCR2-Dependent Innate Allergic Inflammation in the Lung. J Immunol. 2012 Sep 1;189(5):2545-52. PMID: 22851704; PMCID: PMC3424300.

Roy RM, Klein BS. Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe. 2012 May 17;11(5):436-46. PMID: 22607797; PMCID: PMC3401965.

Feire AL, Roy RM, Manley K, Compton T. The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. J Virol. 2010 Oct;84(19):10026-37. PMID: 20660204; PMCID: PMC2937812.

Roy RM, Paes HC, Nanjappa SG, Sorkness R, Gasper D, Sterkel A, Wüthrich M, Klein BS. Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation. MBio. 2013 Apr 2;4(2). PMID: 23549917; PMCID:PMC3622928.

Roy RM, Klein BS. Fungal glycan interactions with epithelial cells in allergic airway disease. Curr Opin Microbiol. 2013 Aug;16(4):404-8. PMID: 23602359; PMCID: PMC3893682.

Brandhorst TT, Roy R, Wüthrich M, Nanjappa S, Filutowicz H, Galles K, Tonelli M, McCaslin DR, Satyshur K, Klein B. Structure and function of a fungal adhesion that binds heparin and mimics thrombospondin-1 by blocking T cell activation and effector function. PLoS Pathog. 2013 Jul;9(7):e1003464. PMID: 23853587; PMCID: PMC3708853.