Undergraduate education

University of Washington – Seattle, BS, 2000

Years in MSTP



Cellular and molecular biology, 2007


Anna Huttenlocher, MD

Thesis title

The Roles of Talin1 and Calpain in T Cell Adhesion and Migration


Pathology, University of Washington, 2009-2013


Hematopathology, University of Washington-Seattle, School of Medicine, 2013-2014

Current position

Clinical Pathologist, Western Washington Pathology, Tacoma, Washington

Undergraduate and/or masters publications

Niklasson B, Heller KE, Schønecker B, Bildsøe M, Daniels T, Hampe CS, Widlund P, Simonson WT, Schaefer JB, Rutledge E, Bekris L, Lindberg AM, Johansson S, Ortqvist E, Persson B, Lernmark A. Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus. Int J Exp Diabesity Res. 2003 Jan-Mar;4(1):35-44. PMID: 12745669; PMCID: PMC2480497.

Chessler SD, Hampe CS, Ortqvist E, Simonson WT, Bekris L. Immune reactivity to GAD25 in type 1 diabetes mellitus. Autoimmunity. 2002 Aug;35(5):335-41. PMID: 12515288.

Chessler SD, Simonson WT, Sweet IR, Hammerle LP. Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. Diabetes. 2002 Jun;51(6):1763-71. PMID: 12031963.

Barry SC, Ramesh N, Lejnieks D, Simonson WT, Kemper L, Lernmark A, Osborne WR. Glucose-regulated insulin expression in diabetic rats. Hum Gene Ther. 2001 Jan 20;12(2):131-9. PMID: 11177550.

Lee ES, Jiang J, Sund GC, Simonson WT, Graham J, Dietsch G, Schimpf B, Bieg S, Peterman G, Lernmark A. Recombinant human platelet-activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes-prone BB rat. Diabetes. 1999 Jan;48(1):43-9. PMID: 9892221.

PhD publications

Wernimont SA, Legate KR, Simonson WT, Fassler R, Huttenlocher A. PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23. PMID: 20855869; PMCID: PMC3014605.

Wernimont SA, Simonson WT, Greer PA, Seroogy CM, Huttenlocher A. Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS One. 2010 May 7;5(5):e10513. PMID: 20479866; PMCID: PMC2866319.

Schartner JM, Simonson WT, Wernimont SA, Nettenstrom LM, Huttenlocher A, Seroogy CM. Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions. J Biol Chem. 2009 Dec 11;284(50):34674-81. PMID: 19833735; PMCID: PMC2787330.

Simonson WT, Markovina S, Grossman WJ, Lokuta MA, Doan AT, Seroogy CM, Huttenlocher A. Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. Ann Allergy Asthma Immunol. 2009 Feb;102(2):170-1. PMID: 19230472.

Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE. Natural killer T-cell autoreactivity leads to a specialized activation state. Blood. 2008 Nov 15;112(10):4128-38. PMID: 18779390; PMCID: PMC2581981.

Wernimont SA, Cortesio CL, Simonson WT, Huttenlocher A. Adhesions ring: a structural comparison between podosomes and the immune synapse. Eur J Cell Biol. 2008 Sep;87(8-9):507-15. PMID: 18343530; PMCID: PMC2570187.

Simonson WT, Franco SJ, Huttenlocher A. Talin1 regulates TCR-mediated LFA-1function. J Immunol. 2006 Dec 1;177(11):7707-14. PMID: 17114441.

Franco SJ, Senetar MA, Simonson WT, Huttenlocher A, McCann RO. The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions. Cell Motil Cytoskeleton. 2006 Sep;63(9):563-81. PMID: 16830345.

Su LT, Agapito MA, Li M, Simonson WT, Huttenlocher A, Habas R, Yue L, Runnels LW. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem. 2006 Apr 21;281(16):11260-70. PMID: 16436382; PMCID: PMC3225339.