Lafayette College, BS, 1993
Years in MSTP
W. Wallace Cleland, PhD
Insight Into the Mechanism of Enzymatic Phosphoryl Transfer Through Investigation of Transition State Structures
Rehabilitation medicine, Northwestern University, 2001-2004
Professor & Chair, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, School of Medicine
Gerratana B, Sowa GA, Cleland WW. Characterization of the transition-state structures and mechanisms for the isomerization and cleavage reactions uridine 3'-m-Nitrobenzyl phosphate. J Am Chem Soc. 2000 Dec 27; 122(51):12615-12621.
Poyner RR, Laughlin LT, Sowa GA, Reed GH. Toward identification of acid/base catalysts in the active site of enolase: comparison of the properties of K345A, E168Q, and E211Q variants. Biochemistry. 1996 Feb 6;35(5):1692-9. PMID: 8634301.
Hengge AC, Sowa GA, Wu L, Zhang ZY. Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction. Biochemistry. 1995 Oct 31;34(43):13982-7. PMID: 7577995.
Sowa GA, Hengge AC, Cleland WW. O-18 isotope effects support a concerted mechanism for ribonuclease A. Journal of the American Chemical Society. 1997 Mar;119(9):2319-2320.