Undergraduate education

University of Illinois at Urbana-Champaign, BS, 1993

Years in MSTP

1993-2002

PhD

Cellular and molecular biology, 2000

Mentor

Judd Aiken, PhD

Thesis title

The Role of Mitochondrial DNA Deletion Mutations in the Pathogenesis of Aging: Studies in Rodent Heart and Skeletal Muscle

Residency

Internal medicine, University of Wisconsin-Madison, 2003-2005

Fellowship

Geriatric medicine, University of Washington, 2005-2007

Current position

Associate professor, Department of Medicine-Geriatrics, University of California-Los Angeles, School of Medicine

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PhD publications

McKiernan SH, Tuen VC, Baldwin K, Wanagat J, Djamali A, Aiken JM. Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2007 Jun;292(6):F1751-60. PMID: 17344189.

Hacker TA, McKiernan SH, Douglas PS, Wanagat J, Aiken JM. Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H304-11. PMID: 16143657.

Bua EA, McKiernan SH, Wanagat J, McKenzie D, Aiken JM. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. J Appl Physiol. 2002 Jun;92(6):2617-24. PMID: 12015381.

Aiken J, Bua E, Cao Z, Lopez M, Wanagat J, McKenzie D, McKiernan S. Mitochondrial DNA deletion mutations and sarcopenia. Ann N Y Acad Sci. 2002 Apr;959:412-23. PMID: 11976214.

Wanagat J, Wolff MR, Aiken JM. Age-associated changes in function, structure and mitochondrial genetic and enzymatic abnormalities in the Fischer 344 x Brown Norway F(1) hybrid rat heart. J Mol Cell Cardiol. 2002 Jan;34(1):17-28. PMID: 11812161.

Cao Z, Wanagat J, McKiernan SH, Aiken JM. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res. 2001 Nov 1;29(21):4502-8. PMID: 11691938; PMCID: PMC60181.

Wanagat J, Cao Z, Pathare P, Aiken JM. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J. 2001 Feb;15(2):322-32. PMID: 11156948.

Wanagat J, Allison DB, Weindruch R. Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci. 1999 Dec;52(2 Suppl):35-40. PMID: 10630588.

Keller ET, Wanagat J, Ershler WB. Molecular and cellular biology of interleukin-6 and its receptor. Front Biosci. 1996 Dec 1;1:d340-57. PMID: 9159238.

McKenzie D, Bua E, McKiernan S, Cao Z, Wanagat J, Aiken JM. Mitochondrial DNA deletion mutations: a causal role in sarcopenia. Eur J Biochem. 2002 Apr;269(8):2010-5. Review. PMID: 11985577.

Herbst A, Widjaja K, Nguy B, Lushaj EB, Moore TM, Hevener AL, McKenzie D, Aiken JM, Wanagat J. Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1327-1333. PMID: 28460005.