Undergraduate education

University of Chicago, BS, 2004

Years in MSTP

2004-2013

PhD

Cellular and molecular biology, 2011

Mentor

Anna Huttenlocher, MD

Thesis title

Using integrins to fine tune CD4+ T cell responses: how the integrin regulatory proteins calpain, PIPKIgamma90, talin and focal adhesion kinase work together to regulate CD4+ T cell activation

Residency

Obstetrics and gynecology, University of Iowa, 2013-2017

Fellowship

Maternal-fetal medicine, University of Iowa, 2017-

Current position

Fellow, Department of Obstetrics and Gynecology, University of Iowa, College of Medicine

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Undergraduate and/or masters publications

Welti R, Mui E, Sparks A, Wernimont S, Isaac G, Kirisits M, Roth M, Roberts CW, Botté C, Maréchal E, McLeod R. Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids. Biochemistry. 2007 Dec 4;46(48):13882-90. PMID: 17988103; PMCID: PMC2576749.

Muench SP, Prigge ST, Zhu L, Kirisits MJ, Roberts CW, Wernimont S, McLeod R, Rice DW. Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):604-6. PMID: 16754994; PMCID: PMC2243092.

Samuel BU, Hearn B, Mack D, Wender P, Rothbard J, Kirisits MJ, Mui E, Wernimont S, Roberts CW, Muench SP, Rice DW, Prigge ST, Law AB, McLeod R. Delivery of antimicrobials into parasites. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14281-6. PMID: 14623959; PMCID: PMC283583.

PhD publications

Sackmann EK, Berthier E, Young EW, Shelef MA, Wernimont SA, Huttenlocher A, Beebe DJ. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012 Oct 4;120(14):e45-53. PMID: 22915642; PMCID: PMC3466974.

Wernimont SA, Wiemer AJ, Bennin DA, Monkley SJ, Ludwig T, Critchley DR, Huttenlocher A. Contact-dependent T cell activation and T cell stopping require talin1. J Immunol. 2011 Dec 15;187(12):6256-67. PMID: 22075696; PMCID: PMC3237745.

Wiemer AJ, Wernimont S, Huttenlocher A. Live imaging of LFA-1-dependent T-cell motility and stop signals. Methods Mol Biol. 2012;757:191-204. PMID: 21909914.

Wernimont SA, Legate KR, Simonson WT, Fassler R, Huttenlocher A. PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23. PMID: 20855869; PMCID: PMC3014605.

Cortesio CL, Wernimont SA, Kastner DL, Cooper KM, Huttenlocher A. Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA syndrome. Arthritis Rheum. 2010 Aug;62(8):2556-8. PMID: 20506269; PMCID: PMC2921034.

Wernimont SA, Simonson WT, Greer PA, Seroogy CM, Huttenlocher A. Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS One. 2010 May 7;5(5):e10513. PMID: 20479866; PMCID: PMC2866319.

Wiemer AJ, Lokuta MA, Surfus JC, Wernimont SA, Huttenlocher A. Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst. Mol Immunol. 2010 Jan;47(4):894-902. PMID: 19889458; PMCID: PMC2814964.

Schartner JM, Simonson WT, Wernimont SA, Nettenstrom LM, Huttenlocher A, Seroogy CM. Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions. J Biol Chem. 2009 Dec 11;284(50):34674-81. PMID: 19833735; PMCID: PMC2787330.

Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE. Natural killer T-cell autoreactivity leads to a specialized activation state. Blood. 2008 Nov 15;112(10):4128-38. PMID: 18779390; PMCID: PMC2581981.

Wernimont SA, Cortesio CL, Simonson WT, Huttenlocher A. Adhesions ring: a structural comparison between podosomes and the immune synapse. Eur J Cell Biol. 2008 Sep;87(8-9):507-15. PMID: 18343530; PMCID: PMC2570187.

Wiemer AJ, Wernimont SA, Cung TD, Bennin DA, Beggs HE, Huttenlocher A. The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation. Biochem Pharmacol. 2013 Sep 15;86(6):770-81. PMID: 23928188; PMCID: PMC3762933.

Mathis L, Wernimont S, Affentranger S, Huttenlocher A, Niggli V. Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation. PeerJ. 2013 Aug 29;1:e131. PMID: 24010013; PMCID: PMC3757496.