Headshot of Sara Berman

Undergraduate education

Haverford college - BS (2010)

Years in MSTP

2012-

PhD program

Neuroscience

Mentor

Sterling Johnson, PhD

Research interest

My graduate research examines the interplay between intracranial arterial health and Alzheimer’s disease (AD) pathology in a longitudinal framework. It is becoming increasingly accepted that dementia, particularly dementia due to AD, is often multifactorial in nature; my work strives to better understand the link between AD pathology as assessed via cerebrospinal fluid analytes, PET imaging and cognition with cerebrovascular health using a novel 4D flow MRI method.

Undergraduate and/or masters publications

Berman S, Morris A. Nitric oxide as a putative retinal axon pathfinding and target recognition cue in Xenopus laevis. Impulse (Columbia). 2011 Jan 1;2010:1-12. PMID: 21847432; PMCID: PMC3155770.

PhD publications

Dempsey RJ, Varghese T, Jackson DC, Wang X, Meshram NH, Mitchell CC, Hermann BP, Johnson SC, Berman SE, Wilbrand SM. Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis. J Neurosurg. 2018 Jan:128(1):111-119. PMID: 28298048; PMCID: PMC5592121.

Nicholas C, Hoscheidt SM, Clark LR, Racine AM, Berman SE, Koscik RL, Maritza Dowling N, Asthana S, Christian BT, Sager MA, Johnson SC. Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Soc Cogn Affect Neurosci. 2017 Jun 1;12(6):993-1000. PMID: 28402542; PMCID: PMC5472120.

Koscik RL, Berman SE, Clark LR, Mueller KD, Okonkwo OC, Gleason CE, Hermann BP, Sager MA, Johnson SC. Intraindividual Cognitive Variability in Middle Age Predicts Cognitive Impairment 8-10 Years Later: Results from the Wisconsin Registry for Alzheimer's Prevention. J Int Neuropsychol Soc. 2016 Nov;22(10):1016-1025. PMID: 27903330; PMCID: PMC5147731.

Berman SE, Rivera-Rivera LA, Clark LR, Racine AM, Keevil JG, Bratzke LC, Carlsson CM, Bendlin BB, Rowley HA, Blennow K, Zetterberg H, Asthana S, Turski P, Johnson SC, Wieben O. Intracranial Arterial 4D-Flow is Associated with Metrics of Brain Health and Alzheimer's Disease. Alzheimers Dement (Amst). 2015 Dec 1;1(4):420-428. PMID: 26693176; PMCID: PMC4674833.

Rivera-Rivera LA, Turski P, Johnson KM, Hoffman C, Berman SE, Kilgas P, Rowley HA, Carlsson CM, Johnson SC, Wieben O. 4D flow MRI for intracranial hemodynamics assessment in Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Oct;36(10):1718-1730. PMID: 26661239; PMCID: PMC5076787; PMCID: PMC5464708.

Berman SE, Wang X, Mitchell CC, Kundu B, Jackson DC, Wilbrand SM, Varghese T, Hermann BP, Rowley HA, Johnson SC, Dempsey RJ. The relationship between carotid artery plaque stability and white matter ischemic injury. Neuroimage Clin. 2015 Aug 22;9:216-22. PMID: 26448914; PMCID: PMC4572385.

Racine AM, Koscik RL, Berman SE, Nicholas CR, Clark LR, Okonkwo OC, Rowley HA, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Gleason CE, Carlsson CM, Johnson SC. Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain. 2016 Aug;139(Pt 8):2261-74. PMID: 27324877; PMCID: PMC4958904.

Rivera-Rivera LA, Schubert T, Turski P, Johnson KM, Berman SE, Rowley HA, Carlsson CM, Johnson SC, Wieben O. Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. J Cereb Blood Flow Metab. 2017 Jun;37(6):2149-2158. PMID: 27492950.

Hoscheidt SM, Kellawan JM, Berman SE, Rivera-Rivera LA, Krause RA, Oh JM, Beeri MS, Rowley HA, Wieben O, Carlsson CM, Asthana S, Johnson SC, Schrage WG, Bendlin BB. Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. J Cereb Blood Flow Metab. 2017 Jun;37(6):2249-2261. PMID: 27488909; PMCID: PMC5464714.

Racine AM, Clark LR, Berman SE, Koscik RL, Mueller KD, Norton D, Nicholas CR, Blennow K, Zetterberg H, Jedynak B, Bilgel M, Carlsson CM, Christian BT, Asthana S, Johnson SC. Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease. J Alzheimers Dis. 2016 Oct 18;54(4):1395-1408. PMCID: PMC5074904.

Berman SE, Clark LR, Rivera-Rivera LA, Norton D, Racine AM, Rowley HA, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Asthana S, Turski P, Wieben O, Johnson SC. Intracranial Arterial 4D Flow in Individuals with Mild Cognitive Impairment is Associated with Cognitive Performance and Amyloid Positivity. J Alzheimers Dis; 60(1):243-252. PMID: 28826187; PMCID: PMC5617115.

Berman SE, Koscik RL, Clark LR, Mueller KD, Bluder L, Galvin JE, Johnson SC. Use of the Quick Dementia Rating System (QDRS) as an Initial Screening Measure in a Longitudinal Cohort at Risk for Alzheimer's Disease. JAD Rep. 2017;1(1):9-13. PMID: 28819654; PMCID: PMC5557032.

Nicholas CR, Dowling NM, Racine AM, Clark LR, Berman SE, Koscik RL, Asthana S, Hermann B, Sager MA, Johnson SC. Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer's Disease. J Int Neuropsychol Soc. 2017 Sep;23(8):617-626. PMID: 28693655; PMCID: PMC5754023.

Dempsey RJ, Jackson DC, Wilbrand SM, Mitchell CC, Berman SE, Johnson SC, Meshram NH, Varghese T, Hermann BP. The Preservation of Cognition 1 Yr After Carotid Endarterectomy in Patients With Prior Cognitive Decline. Neurosurgery. 2017 Jun 1. [Epub ahead of print] PMID: 28575478; PMCID: PMC5711632.

Racine AM, Merluzzi AP, Adluru N, Norton D, Koscik RL, Clark LR, Berman SE, Nicholas CR, Asthana S, Alexander AL, Blennow K, Zetterberg H, Kim WH, Singh V, Carlsson CM, Bendlin BB, Johnson SC. Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults. Brain Imaging Behav. 2017 Jun 9. [Epub ahead of print] PMID: 28600739.

Clark LR, Berman SE, Rivera-Rivera LA, Hoscheidt SM, Darst BF, Engelman CD, Rowley HA, Carlsson CM, Asthana S, Turski P, Wieben O, Johnson SC. Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease. Alzheimers Dement (Amst). 2017 Jan 23;7:48-55. PMID: 28239641; PMCID: PMC5318539.

Johnson SC, Koscik RL, Jonaitis EM, Clark LR, Mueller KD, Berman SE, Bendlin BB, Engelman CD, Okonkwo OC, Hogan KJ, Asthana S, Carlsson CM, Hermann BP, Sager MA. The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions. Alzheimers Dement (Amst). 2017 Dec 8;10:130-142. eCollection 2018. PMID: 29322089; PMCID: PMC5755749.