Headshot of Mazdak Bradberry

Undergraduate education

Northwestern University - BA (2013)

Years in MSTP

2013-

PhD program

Cellular and molecular biology

Mentor

Ed Champman, PhD

Research interest

Synaptic vesicle biochemistry and physiology

Undergraduate and/or masters publications

Srivastava DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Moskal JR, Casanova MF, Waters J, Penzes P. Social, communication, and cortical structural impairments in Epac2-deficient mice. J Neurosci. 2012 Aug 22;32(34):11864-78. PMID: 22915127; PMCID: PMC3520089.

PhD publications

Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB. Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin. J Mol Biol. 2019 May 17;431(11):2112-2126. PMID: 31004665; PMCID: PMC6599597.

Ruhl DA, Bomba-Warczak E, Watson ET, Bradberry MM, Peterson TA, Basu T, Frelka A, Evans CS, Briguglio JS, Basta T, Stowell MHB, Savas JN, Roopra A, Pearce RA, Piper RC, Chapman ER. Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways. Nat Commun. 2019 Aug 6;10(1):3532. PMID: 31387992; PMCID: PMC6684635.

Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER. Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron. 2020 Apr 21. [Epub ahead of print] PMID: 32362337.

Bradberry MM, Bao H, Lou X, Chapman ER. PIP2 drives Ca2+-independent membrane penetration by the tandem C2 domain proteins synaptotagmin-1 and Doc2β. J Biol Chem. 2019 Jul 12;294(28):10942-10953. PMID: 31147445. PMCID: PMC31147445.

Bendahmane M, Bohannon KP, Bradberry MM, Rao TC, Schmidtke MW, Abbineni PS, Chon NL, Tran S, Lin H, Chapman ER, Knight JD, Anantharam A. The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion. Mol Biol Cell. 2018 Apr 1;29(7):834-845. PMID: 29444959; PMCID: PMC5905296.

Courtney NA, Briguglio JS, Bradberry MM, Greer C, Chapman ER. Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release. Neuron. 2018 Jun 6;98(5):977-991. PMID: 29754754; PMCID: PMC6090561.

Rao TC, Santana Rodriguez Z, Bradberry MM, Ranski AH, Dahl PJ, Schmidtke MW, Jenkins PM, Axelrod D, Chapman ER, Giovannucci DR, Anantharam A. Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules. J Gen Physiol. 2017 Aug 7;149(8):763-780. PMID: 28687607; PMCID: PMC5560776.