Headshot of Ryan Denu

Undergraduate education

University of Wisconsin-Madison - BS (2012)

Years in MSTP

2012-

PhD program

Cellular and Molecular Biology

Mentor

Mark Burkard, MD, PhD

Thesis title

Causes and Consequences of Centrosome Amplification in Cancer

Undergraduate and/or masters publications

Denu RA, Burkard ME. Synchronous Bilateral Breast Cancer in a Patient With Nager Syndrome. Clin Breast Cancer. 2017 Jun; 17(3):e151-e153. PMID: 28139434; PMCID: PMC5446269.

Denu RA. Estimates of Cancer Deaths Prevented by Raising Cigarette Taxes. JAMA Intern Med. 2017 May 1;177(5):739. PMID: 28460094

Denu RA, Hampton JM, Currey A, Anderson RT, Cress RD, Fleming ST, Lipscomb J, Sabatino SA, Wu XC, Wilson JF, Trentham-Dietz A. Influence of patient, physician, and hospital characteristics on the receipt of guideline-concordant care for inflammatory breast cancer. Cancer Epidemiol. 2016 Feb;40:7-14. PMID: 26605428; PMCID: PMC4738104.

Kim J, Breunig MJ, Escalante LE, Bhatia N, Denu RA, Dollar BA, Stein AP, Hanson SE, Naderi N, Radek J, Haughy D, Bloom DD, Assadi-Porter FM, Hematti P. Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets. Cytotherapy. 2012 Sep;14(8):925-35. PMID: 22571381; PMCID: PMC3537170.

Kim J, Denu RA, Dollar BA, Escalante LE, Kuether JP, Callander NS, Asimakopoulos F, Hematti P. Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. Br J Haematol. 2012 Aug;158(3):336-46. PMID: 22583117; PMCID: PMC3395762.

Asimakopoulos F, Kim J, Denu RA, Hope C, Jensen JL, Ollar SJ, Hebron E, Flanagan C, Callander N, Hematti P. Macrophages in multiple myeloma: emerging concepts and therapeutic implications. Leuk Lymphoma. 2013 Oct;54(10):2112-21. PMID: 23432691; PMCID: PMC3686978

Denu RA, Rush PS, Ahrens SE, Westergaard RP. Idiopathic CD4 lymphocytopenia with giant cell arteritis and pulmonary mucormycosis. Medical Mycology Case Reports. 2014 Nov 4;6:73-75. PMID: 25473601; PMCID: PMC4246401.

Denu RA, Nemcek S, Bloom DD, Goodrich AD, Kim J, Mosher DF, Hematti P. Fibroblasts and Mesenchymal Stromal/Stem Cells Are Phenotypically Indistinguishable. Acta Haematol. 2016 May 18;136(2):85-97. PMID: 27188909.

PhD publications

Denu RA, Lobo RH, Mattison RJ. Management of differentiation syndrome in an elderly patient with acute promyelocytic leukemia who subsequently developed refractory anemia with ring sideroblasts. Leuk Lymphoma. 2016 Dec;57(12)2905-2907. PMID: 27073113; PMCID: PMC5588882.

Yu W, Denu RA, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM. Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies. J Biol Chem. 2016 Feb 12;291(7):3268-79. PMID: 26631723; PMCID: PMC4751373.

Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin J, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. Identification of selective lead compounds for treatment of high-ploidy breast cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59. PMID: 26586723; PMCID: PMC4707107.

Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016 Jan 29;16(1):47. PMID: 26832928; PMCID: PMC4734858.

Denu RA, Hematti P. Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxid Med Cell Longev. 2016;2016:2989076. PMID: 27413419; PMCID: PMC4928004.

Denu RA. SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation. Oxid Med Cell Longev. 2017;2017:5841716. PMID: 28717408; PMCID: PMC5499245.

Denu RA, Mendonca EA, Fost N. Potential Yield of Imminent Death Kidney Donation. Am J Transplant. 2018 Feb;18(2):486-91. PMID: 28975705.

Denu RA, Rosenberg SA, Howard SP. Familial trigeminal neuralgia treated with stereotactic radiosurgery: a case report and literature review. Journal of Radiation Oncology. 2017 June;6(2):149-152. PMID: 29201285; PMCID: PMC5705085.

Denu RA, Hampton JM, Currey A, Anderson RT, Cress RD, Fleming ST, Lipscomb J, Wu XC, Wilson JF, Trentham-Dietz A. Racial and Socioeconomic Disparities Are More Pronounced in Inflammatory Breast Cancer Than Other Breast Cancers. J Cancer Epidemiol. 2017;2017:7574946. PMID: 28894467; PMCID: PMC5574219.

Denu RA, Shabbir M, Nihal M, Singh CK, Longley BJ, Burkard ME, Ahmad N. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. Mar;16(3):517-527. PMID: 29330283; PMCID: PMC5835182.

Denu RA. Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening. JAMA Oncol. 2018 Jun 1;4(6):883. PMID:29543935; PMCID: PMC6002905.