Profile of Jack Hunt

Undergraduate education

Stanford University - BA (2009)

Years in MSTP

2013-

PhD program

Cellular and Molecular Biology

Mentor

Barb Bendlin, PhD

Research interest

I study risk factors and early pathogenic processes that contribute to the development of sporadic Alzheimer’s Disease (AD). My research has two major focuses: characterizing the relationship between an individual's community-level socioeconomic context and changes in AD-related brain regions and connectivity (white matter) tracts; and understanding the interplay between white matter tract microstructural change and the accumulation of hallmark pathological AD proteins during the aging process in cognitively healthy individuals.

Undergraduate and/or masters publications

Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H. Loss of F-box Only Protein 2 (Fbxo2) Disrupts Levels and Localization of Select NMDA Receptor Subunits, and Promotes Aberrant Synaptic Connectivity. J Neurosci. 2015 Apr 15;35(15):6165-78. PMID: 25878288; PMCID: PMC4397610.

Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012 Jul 2;209(7):1325-34. PMID: 22734047; PMCID: PMC3405500.

Olsen RK, Nichols EA, Chen J, Hunt JF, Glover GH, Gabrieli JD, Wagner AD. Performance-related sustained and anticipatory activity in human medial temporal lobe during delayed match-to-sample. J Neurosci. 2009 Sep 23;29(38):11880-90. PMID: 19776274; PMCID: PMC2775810.

Atkin G, Hunt J, Minakawa E, Sharkey L, Tipper N, Tennant W, Paulson HL. F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing. J Biol Chem. 2014 Mar 7;289(10):7038-48. PMID: 24469452; PMCID: PMC3945364.

PhD publications

Hunt JFVS, Li M, Zhao X, Bhattacharyya A. Using Human Neural Progenitor Cell Models to Conduct Large-Scale Drug Screens for Neurological and Psychiatric Diseases. Methods Mol Biol. 2019;1942:79-88. PMID: 30900177.

Li M, Hunt JFVS, Bhattacharyya A, Zhao X. One-Step Generation of Seamless Luciferase Gene Knockin Using CRISPR/Cas9 Genome Editing in Human Pluripotent Stem Cells. Methods Mol Biol. 2019;1942:61-69. PMID: 30900175.