Headshot of Richard Merkhofer

Undergraduate education

Colgate University - BA (2012)

Years in MSTP

2013-

PhD program

Cell and Molecular Biology

Mentor

Bruce Klein, MD

Thesis title

Variation at Interleukin-6 and genetic susceptibility to blastomycosis

Undergraduate publications

Bartakova A, Alvarez-Delfin K, Weisman AD, Salero E, Raffa GA, Merkhofer RM Jr, Kunzevitzky NJ, Goldberg JL. Novel Identity and Functional Markers for Human Corneal Endothelial Cells. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2749-62. PMID: 27196322; PMCID: PMC4884060.

Hoffmann KM, Million-Perez HR, Merkhofer R, Nicholson H, Rowlett RS. Allosteric reversion of Haemophilus influenzae β-carbonic anhydrase via a proline shift. Biochemistry. 2015 Jan 20;54(2):598-611. PMID: 25506786.

Moysidis SN, Alvarez-Delfin K, Peschansky VJ, Salero E, Weisman AD, Bartakova A, Raffa GA, Merkhofer RM Jr, Kador KE, Kunzevitzky NJ, Goldberg JL. Magnetic field-guided cell delivery with nanoparticle-loaded human corneal endothelial cells. Nanomedicine. 2015 Apr;11(3):499-509. PMID: 25596075; PMCID: PMC4691344.

Louradour I, Monteiro CC, Inbar E, Ghosh K, Merkhofer R, Lawyer P, Paun A, Smelkinson M, Secundino N, Lewis M, Erram D, Zurek L, Sacks D. The midgut microbiota plays an essential role in sand fly vector competence for Leishmania major. Cell Microbiol. 2017 Oct;19(10). PMID: 28580630; PMCID: PMC5587349.

PhD publications

Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 Apr 8;27(4):614-628. PMID: 32130954.

Merkhofer RM, Klein BS. Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi. Front Cell Infect Microbiol. 2020 Feb 28. 10:69. eCollection 2020. Review. PMID: 32185141; PMCID: PMC7058545.

Merkhofer RM Jr, O'Neill MB, Xiong D, Hernandez-Santos N, Dobson H, Fites JS, Shockey AC, Wuethrich M, Pepperell CS, Klein BS. Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus. MBio. 2019 Jun 18;10(3). PMID: 31213563; PMC6581865.

Wang H, Lee TJ, Fites SJ, Merkhofer R, Zarnowski R, Brandhorst T, Galles K, Klein B, Wüthrich M. Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination. PLoS Pathog. 2017 Aug 9;13(8):e1006568. eCollection 2017 Aug. PubMed PMID: 28793349; PMCID: PMC5565193.

Kujoth GC, Sullivan TD, Merkhofer R, Lee TJ, Wang H, Brandhorst T, Wüthrich M, Klein BS. CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis. MBio. 2018 Apr 3;9(2). pii: e00412-18. PMID:29615501; PMCID: PMC5885028.