Yash Somnay

Undergraduate education

University of Michigan - BS (2009)

Years in MSTP

2012-

PhD program

Cellular and Molecular Pathology

Mentor

Herb Chen, MD

Thesis title

Targeted activation of Notch3 signaling in the treatment of advanced thyroid cancer

Undergraduate and/or masters publications

Murphy JD, Spalding AC, Somnay YR, Markwart S, Ray ME, Hamstra DA. Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature. Clin Cancer Res. 2009 Jan 15;15(2):589-96. PMID: 19147764.

Murphy JD, Lucas DR, Somnay YR, Hamstra DA, Ray ME. Gemcitabine-mediated radiosensitization of human soft tissue sarcoma. Transl Oncol. 2008 Mar;1(1):50-6. PMID: 18607508; PMCID: PMC2510764.

PhD publications

Somnay YR, Craven M, McCoy KL, Carty SE, Wang TS, Greenberg CC, Schneider DF. Improving diagnostic recognition of primary hyperparathyroidism with machine learning. Surgery. 2017 Apr;161(4):1113-1121. PMID: 27989606; PMCID: PMC5367958.

Somnay Y, Lubner S, Gill H, Matsumura JB, Chen H. The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids. Cancer Gene Ther. 2016 Oct;23(10):348-354. PMID: 27632933; PMCID: PMC5083201.

Somnay YR, Yu XM, Lloyd RV, Leverson G, Aburjania Z, Jang S, Jaskula-Sztul R, Chen H. Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosis. Cancer. 2017 Mar 1;123(5):769-782. PMID: 27861750; PMCID: PMC5319883.

Somnay YR, Dull BZ, Eide J, Jaskula-Sztul R, Chen H. Chrysin suppresses achaete-scute complex-like 1 and alters the neuroendocrine phenotype of carcinoids. Cancer Gene Ther. 2015 Oct;22(10):496-505. PMID: 26403073; PMCID: PMC4607661.

Somnay YR, Weinlander E, Alfhefdi A, Schneider D, Sippel RS, Chen H. Radioguided parathyroidectomy for tertiary hyperparathyroidism. J Surg Res. 2015 May 15;195(2):406-11. PMID: 25770735. PMCID: PMC4422627.

Somnay Y, Simon K, Harrison AD, Kunnimalaiyaan S, Chen H, Kunnimalaiyaan M. Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro. Anticancer Drugs. 2013 Jan;24(1):66-72. PMID: 23147412; PMCID: PMC3510354.

Somnay Y, Chen H, Kunnimalaiyaan M. Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro. Neuroendocrinology. 2013;97(2):183-92. PMID: 22965070; PMCID: PMC3546174.

Somnay Y, Schneider D and Mazeh H. Thyroid: Medullary carcinoma. In Huret JL (ed.), Atlas of Genetics and Cytogenetics in Oncology and Haematology. Vandœuvre-lès-Nancy: INIST-CNRS. 2012:291-296.

Weinlander E, Somnay Y, Harrison AD, Wang C, Cheng YQ, Jaskula-Sztul R, Yu XM, Chen H. The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growth. J Surg Res. 2014 Jul;190(1):191-7. Epub 2014 Feb 28. PMID: 24679699. PMCID: PMC4063213.

Somnay YR, Weinlander E, Schneider DF, Sippel RS, Chen H. The effect of cinacalcet on intraoperative findings in tertiary hyperparathyroidism patients undergoing parathyroidectomy. Surgery. 2014 Dec;156(6):1308-14. PMID: 25456900; PMCID: PMC4254721.

Yu XM, Jaskula-Sztul R, Georgen MR, Aburjania Z, Somnay YR, Leverson G, Sippel RS, Lloyd RV, Johnson BP, Chen H. Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression. Clin Cancer Res. 2016 Jul 15;22(14):3582-92. PMID: 26847059; PMCID: PMC5653217.

Somnay Y, Chen H, Kunnimalaiyaan M. The phosphatidylinositol-3-kinase/Akt signaling pathway in neuroendocrine tumors. Global Journal of Biochemistry. 2012;3:3.