Headshot of Ray Zhang

Undergraduate education

University of California-Berkeley - BS (2010)

Years in MSTP

2011-

PhD program

Cellular and Molecular Biology

Mentors

John Kuo, MD, PhD, and Jamey Weichert, PhD

Thesis title

Next Generation Alkylphosphocholine Analogs for Multimodality Imaging and Therapy of Cancer

Undergraduate and/or masters publications

Zhang RR, Schroeder AB, Grudzinski JJ, Rosenthal EL, Warram JM, Pinchuk AN, Eliceiri KW, Kuo JS, Weichert JP. Beyond the margins: real-time detection of cancer using targeted fluorophores. Nat Rev Clin Oncol. 2017 Jun;14(6):347-364. Review. PMID: 28094261; PMCID: PMC5683405.

Zhang RR, Kuo JS. Detection of Human Brain Tumor Infiltration With Quantitative Stimulated Raman Scattering Microscopy. Neurosurgery. 2016 Apr;78(4):N9-N11. PMID: 26986648.

Yin H, Hu M, Zhang R, Shen Z, Flatow L, You M. MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. J Biol Chem. 2012 Mar 23;287(13):9817-26. PMID: 22308024; PMCID: PMC3323059.

Hu M, Wang F, Li X, Rogers CQ, Liang X, Finck BN, Mitra MS, Zhang R, Mitchell DA, You M. Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. Hepatology. 2012 Feb;55(2):437-46. doi: 10.1002/hep.24708. PMID: 21953514; PMCID: PMC3253249.

Zhang GG, Ku L, Dilling TJ, Stevens CW, Zhang RR, Li W, Feygelman V. Volumetric modulated arc planning for lung stereotactic body radiotherapy using conventional and unflattened photon beams: a dosimetric comparison with 3D technique. Radiat Oncol. 2011 Nov 9;6:152. PMID: 22070866; PMCID: PMC3354344.

Zhang RR, Feygelman V, Harris ER, Rao N, Moros EG, Zhang GG. Is wax equivalent to tissue in electron conformal therapy planning? A Monte Carlo study of material approximation introduced dose difference. J Appl Clin Med Phys. 2013 Jan 7;14(1):3991. PMID: 23318384.

Javedan K, Feygelman V, Zhang RR, Moros EG, Correa CR, Trotti A, Li W, Zhang GG. Monte Carlo comparison of superficial dose between flattening filter free and flattened beams. Phys Med. 2014 Jun;30(4):503-8. PMID: 24662096.

Everitt H, Hu M, Ajmo JM, Rogers CQ, Liang X, Zhang R, Yin H, Choi A, Bennett ES, You M. Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G38-47. PMID: 23139221; PMCID: PMC3543633.

PhD publications

Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016 Sep 6;13(9):3341-9.  PMID: 27421304; PMCID: PMC5014630.

Zhang RR, Kuo JS. Detection of Human Brain Tumor Infiltration With Quantitative Stimulated Raman Scattering Microscopy. Neurosurgery. 2016 Apr;78(4):N9-N11. PMID: 26986648.

Zhang RR, Pointer KB, Kuo JS. Excitotoxic SLC7A11 Expression Is a Marker of Poor Glioblastoma Survival and a Potential Therapeutic Target. Neurosurgery. 2015 Dec;77(6):N16-7. PMID: 26584321.

Swanson KI, Clark PA, Zhang RR, Kandela IK, Farhoud M, Weichert JP, Kuo JS. Fluorescent Cancer-Selective Alkylphosphocholine Analogs for Intraoperative Glioma Detection. Neurosurgery. 2015 Feb;76(2):115-24. PMID: 25549194; PMCID: PMC4343207.

Pointer KB, Zhang RR, Kuo JS, Dempsey RJ. Detecting brain tumor with Raman scattering microscopy. Neurosurgery. 2014 Feb;74(2):N12-4. PMID: 24435144.

Zhang RR, Pointer KB, Kuo JS, Dempsey RJ. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Neurosurgery. 2014 Dec;75(6):N9-N10. PMID: 25406627.

Pointer KB, Zhang RR, Kuo JS. Oncolytic Herpes Simplex Virus Glioblastoma Therapy is Potentiated by Tumor Necrosis Factor-α Inhibition. Neurosurgery. 2015 Aug;77(2):N18-20. PMID: 26181790.

Zhang RR, Pointer KB, Kuo JS. New Molecular Insights and Potential Therapies for Diffuse Intrinsic Pontine Glioma. Neurosurgery. 2015 Oct;77(4):N13-4. PMID: 26379176.

Zhang RR, Strebe JK, Kuo JS. Heparan Sulfates Promote Amyloid Pathology in Alzheimer Disease. Neurosurgery. 2016 Aug;79(2):N12-3. PMID: 27428635. Policy Exempt – Not a peer-reviewed article.

Zhang RR, Swanson KI, Hall LT, Weichert JP, Kuo JS. Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies. CNS Oncol. 2016 Oct;5(4):223-31. PMID: 27616199; PMCID: PMC5514628.

Zhang RR, Lubin JA, Kuo JS. Bioresorbable Silicon Electronic Sensors for the Brain. Neurosurgery. 2016 Oct;79(4):N19. PMID: 27635973.

Ehrlich NA, Zhang RR, Kuo JS. Anti-Programmed Cell Death Protein-1 Immunotherapy for Glioblastoma is Impaired by Systemic Chemotherapy but Enhanced in Combination With Locally Delivered Chemotherapy. Neurosurgery. 2017 Nov 1;81(5):N34-N36. PMID: 29088467.

Zhang RR, Kuo JS. Reduced H3K27me3 is a New Epigenetic Biomarker for Pediatric Posterior Fossa Ependymomas. Neurosurgery. 2017 Jul 1;81(1):N7-N8. PMID: 28873995.

Lubin JA, Zhang RR, Kuo JS. Zika Virus has Oncolytic Activity Against Glioblastoma Stem Cells. Neurosurgery. 2018 May 1;82(5):E113-E114. PMID: 29669124